yana-notes

Travis Corner

2022-02-19 links: reference:

!Travis Corner #

For all E-celeb misadventures where they have a good overall understanding of things. And tips n’ tricks I hear from notable people that I don’t want to get lost in the journal. Good note format actually for things that require more prosodic annotation. Named in the honor of Travis, like a university.

  • Gbolduev is the ‘anesthesiology book - all there’ guy. I had 3 people contact me from this forum who crashed on Dhea, which actually can cause dangerous hypokalemia. This is not a joke. Progesterone can cause zinc copper imbalance. DHT will cause manganese iron imbalance. Hormones are produced to regulate the body. And not to be taken. they could be used with contrarian endocrinology approach for very short time. To chelate certain mineral or retain the other never heard about this stuff at all, tf?

@Travis #

Biochemistry is inherently somewhat ambiguous because there are so very few absolutes: Most of physiological chemistry is about balance, and in most instances people speak about what cannot even be seen directly. Interpretations and inferences lie on a spectrum of epistemological veracity and certitude, and the body of published science is so large that I dare say nobody could possibly read it all.

  • Post #290 ish ->

  • Cooked/refined foods leads to serotonin spikes. That’s why Travis eats a lot of things raw, for the slow-release amino acids. He also cuts all vegetables into long strands and uses chopstix. Steaming doesn’t affect the majority of vitamins, but it does have implications for the microbiota.

  • 3 coconuts a day. Lol. Or 10oz pack of Deglet Noors, one coconut, 1lb kale, and one pineapple.

  • “Wheat - perhaps the world’s most terrible food”

  • Coconut and goat cheese omelet to supply stearic acid to supply the 15-20% linoleic acid from the egg yolk.

  • The shorter ones (fatty acids) cannot occupy the sn-2 position of the phospholipid, and hence will not displace arachidonic acid without prior elongation. https://raypeatforum.com/community/threads/cacao-butter-strong-anti-cortisol-anti-anxiety-effects.22538/post-317217. Hence, short chain Saturated Fatty acids aren’t as protective/Cancerstatic as Stearic Acid, which is able to occupy it, displacing Arachidonic Acid.

    • Since this position is enriched in arachidonic acid—in most Americans—the release of interferon-γ after immunogenic stimulation (i.e. infection, gluten peptide) leads to prostaglandin formation, a product ensured by the concomitant induction of cyclooxygenase-2 by cytokines which generally accompany the interferon-γ

  • When things are burned many different carbon skeletons are formed as the oxygen and nitrogen atoms leave. For instance: burning tobacco can convert the six‐carboned glucose into Benzene, but anyone who eats grilled food ingests a similar mix. When meat is grilled at a high temperature, the normally spaced double bonds in PUFA migrate towards each other, becoming more stable, so that linoleic acid is turned into “conjugated linoleic acid".

  • I have read Gilbert Ling’s The Association-Induction Hypothesis. I know that the Na⁺/K⁺-ATPase is a unicorn. The cell adsorbs K⁺ ions more like a fixed-charge ion-exchange resin. It does not need active transport, and active transport is thermodynamically impossible anyway. The concept of the Membrane Pump should have been abandoned decades ago.

  • https://raypeatforum.com/community/threads/coconut-oil-is-pure-poison.25281/post-364399F favorite way to refute saturated fat causing heart disease is Ian Pryor’s epidemiological studies on Polynesians and their coconuts.

  • https://raypeatforum.com/community/threads/aspirin-and-asthma.23455/#post-333083

    • A few studies I’d read only about a week ago indicated that the pharmacological inhibition of lipoxygenase had increased prostaglandins by freeing-up more arachidonate available for cyclooxygenase:

  • https://raypeatforum.com/community/threads/test-of-understanding-energy-metabolism-for-a-dummy.18878/#post-254023

    • Q: What is the difference between saturated fat being metabolized and PUFAs being metabolized?: The absorbtion kinetics are different. At the same chain length, saturated fats are more likely to go to the liver (portal vein). Unsaturated fatty acids are more likely to become phospholipids in the intestines and sent through the lymph.
    • #Ankified: This is partly why a PUFA diet lowers Serum Cholesterol: the unsaturated fatty acids form Chylomicrons (these bypass the liver, instead going to lymph + thoracic duct → subclavian vein → adipose/muscle, or something along those lines) where much cholesterol is synthesized. Cholesterol tends to be packed in higher concentrations in lipoproteins from the liver.

PUFA #

  • The skin problems observed were not an omega−6 deficiency nor a B vitamin deficiency, but simply due to increased evapotranspiration consequent of decreased skin lipid desaturation. Some experimenters had even eliminated the possibility of B vitamin deficiency via supplementation, and greatly increased water consumption had been noted in experimental mice.

    • The ’essential fatty acid deficiency’ is not a hormonal condition, or doesn’t depend on eicosanoids, but is simply a consequence of physical membrane effects: The skin scaliness observed correlates with increased water loss through same organ (~2×), also observed by Burr & Burr, and this correlates with decreased H₂O membrane flux—this facilitates cell hydration. The most unsaturated membrane lipid, or docosahexaenoic acid (22∶6), increases lipid bilayer water permeability more than any other.

  • Zellweger Syndrome, a genetic disorder, implicated accumulation of VLCFA that are normally degraded in peroxisomes. Leads to CNS hypomyelination and sensorineural degeneration, craniofacial abnormalities, hepatomegaly, hypotonia, etc. 30% of typical DHA levels.

  • Trace ALA in leaves, milk, beef, etc. gives you all the DHA a person needs.

  • With the loss of only one double bond: cholesterol, pregnenolone, and progesterone transgress into grey matter cell membranes. The increased affinity of the DHA-deficient grey matter for sterols leads to a higher density membrane, reduced glucose flux, and impaired myelination: Pregnenolone and progesterone form a substantial component of myelin, essential steroids accounting for nearly half its mass.

    • I would’ve assumed high-density membranes were a good thing, to prevent it from being ’leaky’ a la the Electron Transport Chain or something. Very interesting.
    • Just as with hydrophilicity, volume also decreases as a function of unsaturation. A cell membrane of lower volume is more glucose-permeant, and besides promoting proper myelination it can also be argued that DHA promotes intelligence by increasing glucose flux.

  • https://raypeatforum.com/community/threads/unintentional-vegan-peating-amazing-so-far.25614/post-371913 GOLD thread.

  • https://raypeatforum.com/community/threads/deep-fried-food-what-is-your-opinion.24715/post-359521

    • The sum of osbond + DHA in the brain appears to be a constant, always falling within the range of 14–17% in the grey matter… we can ensure a proper DHA∶osbond ratio while keeping lipofuscin to a minimum. Lipofuscin increases with age in non-mitotic neurons, slowly lowering their metabolism until death. Postmortem analysis of centenarians reveal that lipofuscin can account for up to 75% of the internal volume in motor neurons.
    • DHA should just be synthesized from α-linoleic acid: I would consider any DHA when not found inside a membrane to be a serious lipofuscin risk, and users on this forum report getting age spots from eating marine oils.
    • I am aware of the idea that ‘all DHA is initially synthesized in the liver before it travels to the brain,’ yet I somewhat doubt this because 18-carbon endogenous lipids are freely found there… since Oleic Acid crosses the BBB, the more stable ALA is more certain.

Microtubules #

Amazoniac Corner #

http://orthomolecular.org/

  • https://www.derangedphysiology.com/main/home https://raypeatforum.com/community/threads/the-amazoniac-corner.32102/post-484501

  • Sarcastic tone is one of your strengths in writing. How are you able to do it with ease? I am funny (I’ve been told by friends, partner, family members, and work colleagues) in real life but when I write in WhatsUp it comes out as weird. How can I translate my face-to-face comedy to writing?

    • It has a pathological root, there isn’t much reason to seek it and the stress motivator can’t be transfered. I guess that what you can get out of this topic is that it’s not about delivering clever lines, but on getting used to the uncomfortable.
    • The previous paragraph is an example of remarking something obvious, that everyone is probably thinking, yet simply by putting it out there and being ok with the awkwardness is enough to build some tension. Tension is a toxin that’s not pleasant, and so we tend to avoid it by release. If you embrace it and learn to not be shaken by it, it can become a skill that’s useful in other areas of life as vvcll because it involves the same principle.
    • You’ll find people that have a piercing eye contact, it takes energy to be comfortable and not feel pressure, but it’s something that can be developed. It’s habit-forming and the stress is eased when you don’t perceive as such, it can be reframed and it’s not a staring contest anyway. It’s a matter of holding it until something else catches the attention rather than because of feeling pressured to look away. It’s like the kid in the elevator that won’t stop staring due to curiosity.
    • You has to be willing to sit in pressure for this, so it’s the opposite of what boris suggested (using emojis, people are not weirded out by odd humor), otherwise you’re making the potential cry every time. It’s easier to release it through whatever means than to adjust according to the situation and run the risk of upsetting people on a bad day. It will inevitably happen, I guess that it’s important to empathize with the inconvenient caused to them and back off, but I wouldn’t feel sorry if there wasn’t something evil in the intention, it’s not about defying anyone.

  • A meal of rice alone would be poor, but with tubers it isn’t a problem. Enough ingredients in a meal lets it become sufficiently complext

  • Ban all colored foods immediately, especially those with warm tones: toxic.

  • Of course then, leafy greens are excluded.

  • Drop milk: unsuitable for human consumption.

  • Seafood is bathed by toxins, if you consume, you become one.

  • Potatoes are killing you, they’re the worst article that Westerners eat. Cut them out before it’s too late.

  • Stop taking killcium supplements.. they obviously kill you.

  • Potassium iodide is destroying you, the right dose is zero.

  • There’s nothing essential about “vitamin” A, unless you consider the way to death essential. It has a biological effect, but so does cocaine. We should strike this poison off the list of nutrients and ignore this monumental misconception.

  • Get Glyphosphate gone since it’s a pilar of all diseases.

  • If you don’t want to get vitamin D toxicity, don’t put it in your mouth. Or skin. It’s this simple. Leave it for its main purpose: hypokalemia-inducing raticide.

  • Forget about coffee, it robs you of precious nutrients which could be used for detoxification.

  • Onions are brutal, shouldn’t be consumed.

  • Menaquinones are fine to take.. to the trash can.

Terma #

https://forums.phoenixrising.me/members/thomas.11847/#recent-content was mostly active from 2014-2016

  • During the night, immunity is modulated by growth hormone and other things that are lost with aging. For ME/CFS they have to stimulate cortisol to achieve immune suppression and resource availability to support the growth and healing afforded by methylation (and presumably impeded by stimulants such as histamine RPF
  • So I took my “need” for sarcosine as a diagnostic marker for NMDA under-activation and with a whole constellation of symptoms settled on taking DHEA before bed instead of more sarcosine. DHEA never did a thing good for me but it was because I took it during the day. I believe it partially fills in for growth hormone decline if you take it at night, since for one both GH and DHEA improve joint recovery in an anabolic way. Progesterone on the other hand increases MMP for joint remodeling, but that’s why it’s not enough to help joints, either GH or DHEA is needed for the actual anabolic effect (and local IGF-1). Of course joints mainly heal during the night (that’s when fat oxidation and carnitine are at their most important), and if I could get my youthful GH spike back, I would certainly do that, but in the meantime, DHEA seems to be the best stand-in. DHEA also is more forgiving for eating closer to bedtime. In one or two ways it’s almost like the “resource abundance” growth hormone but that’s stretching it. The day after I take DHEA + progesterone my stress levels are flat and my brain behaves more similar to the way it does on THC, but with a more relaxed, social and loving character, though I can also reach that more dramatically with varying combinations of supplements + THC. Since progesterone upregulates CB1 that would seem to liken them, and NMDA is likely involved (I also tried sarcosine with THC and there’s something there), but there’s probably more to that story. So I kinda ditched the topic of sarcosine for the time being, yet it was more important than I realized. RPF

Redsun #

Doesn’t like Aspirin at all. Chelates minerals.

  • Even if you controlled water, food weight intake, you can’t control how much water your body wants to hold onto on any given day. There are so many variable to how much water your kidneys excrete its not even funny.
  • In short, Low histamine means weak stomach acid as gastric acid secretion is highly dependent on histamine. Low histamine people (histapenics) lack seasonal allergies but have many food intolerances because digestive secretions are weak. High histamine people (histadelics) tend to digest food very well, lack food intolerances but are prone to seasonal allergies.

Jennifer #

DAIRY-BASED VEGETARIAN

CARBS (40%):

• Bananas—lady finger, mysore, nam wah • Berries (dried)—black raspberries, blueberries, golden raspberries, marionberries, mulberries, red raspberries, strawberries • Dates—sukkari • Figs (dried) • Grapes (juiced)—gum drop, pink muscat • Melon (juiced)—honeydew, snowball • Peaches (dried & fresh)—white • Pears (dried)—bosc • Raw milk • Raw honey—acacia, gallberry, orange blossom, tupelo, wild blueberry, wildflower, wild raspberry • Sugarcane crystals

FATS (35%):

• Cocoa butter • Dairy fat • Egg yolks

PROTEINS (25%):

• Pastured raw certified A2 dairy—Dutch Belted, Guernsey and Jersey • Pastured eggs

HERBS & SEASONINGS:

• Chamomile • Cinnamon—Ceylon • Hibiscus • Kosher salt • Orange peels • Osmanthus • Vanilla beans—Madagascan, Tahitian

SUPPLEMENTS:

• TyroMix • Vitamin D3–ELEA brand • Concentrated butter oil • Mushroom broth

A TYPICAL DAY OF EATING

BREAKFAST: Cinnamon vanilla milkshake, cheesy omelette, and sweetened orange tisane

SNACK: Banana honeydew peach blender ice cream and sweetened blueberry tisane

LUNCH: 1 L of milk, homemade raw cheese curds, and sweetened peach osmanthus tisane

SNACK: Tupelo honey blender ice cream or homemade white chocolate covered dates

DINNER: 1 L of milk, homemade raw cheese curds, and sweetened black raspberry tisane

RECIPES

BLENDER ICE CREAM:

• 1/2 a cup (118 ml) of whole milk • 1/2 a large frozen banana • 1/2 a cup (140 g) of frozen fruit of your choice • Pinch of salt • Vanilla (optional)

Blend and enjoy!

• https://www.cooks.com/recipe/m891e3hm/homemade-ice-cream-in-a-blender.html

CUSTARD:

• https://www.cdkitchen.com/recipes/recs/838/Best-Ever-Baked-Custard82351.shtml

ICE CREAM:

• https://www.theyumblog.com/post/master-ice-cream-recipe

QUICHE:

• https://www.onceuponachef.com/recipes/spinach-quiche.html#tabrecipe

• https://amindfullmom.com/best-classic-quiche-recipe/#comments

SHERBET:

• https://altonbrown.com/recipes/orange-sherbet/

SORBET:

• https://www.foodandwine.com/recipes/melon-sorbet

FOOD & SUPPLEMENT RESOURCES

TYROMIX:

• https://idealabs.ecwid.com/TyroMix-p70230386

VITAMIN D3:

• https://eleadrops.com/

CONCENTRATED BUTTER OIL:

• https://www.greenpasture.org/product/concentrated-butter-oil-liquid/

COCOA POWDER (mycotoxin-free):

• https://www.addictivewellness.com/products/raw-cacao-powder

DAIRY:

• https://www.benediktdairy.com/

• https://www.huckinsfarm.org/

• https://bvpmarket.com/store/raw-a2-dairy

FRUIT:

• https://nwwildfoods.com/view-all-berries/

• https://www.bellaviva.com/collections/organic-dried-fruit

• https://www.localharvest.org/search.jsp?&nm=Fruit

• https://www.etsy.com/search?q=fresh%20fruit%20

• https://miamifruit.org/

• https://tropicalfruitbox.com/

• https://www.etsy.com/shop/Phalwaala

• https://bautistaorganicdates.com/shop-usa.html

• http://datepeople.net/

• https://www.dateland.com/all-date-varieties/

• https://oasisdate.com/

• https://www.chinaranch.com/

• https://shieldsdategarden.com/

• https://www.etsy.com/search?q=fresh%20dates

HONEY:

• https://wendellestate.ca/

• https://swanshoney.com/

• https://amishhoney.com/index.php?route=product/product&product_id=171&path=66

• https://www.weebeehoney.net/

• https://bigislandbees.com/

• https://onehoney.ca/

HERBS & SPICES:

• https://mountainroseherbs.com/catalog/herbs-spices?utm_source=Homepage&utm_medium=ProductCategory&utm_campaign=HerbsAndSpices

• https://www.baktoflavors.com/vanilla-products

KOSHER SALT:

• https://jacobsensalt.com/collections/pure-sea-salt/products/pure-kosher-sea-salt

SUGAR:

• https://www.supervitalfoods.com/shop/sun-dried-cane-juice-crystals

Pax #

  • So basically, cellular signaling is very coherent in the beginning, creating specified networks and hihgly differentiated stem cells. But with inflammation/aging/etc., certain neurotransmitters like GABA and opioids accumulate…

    • As a result of many things, like inefficient functioning of transporters. I mean for example, I can see how a loss of astrocytic EAAT1 is possible if expression of astrocytes is reduced in favor of Microglia, leading to accumulation of extrasynaptic glutamate.
    • This causes. the internalization of their receptors.
      • Downregulation is this decrease in the number of receptors. I feel like I didn’t know this until yesterday.

  • Serotonin inhibition is the entire biological mechanism which Caloric Restriction extends lifespan and explains the macronutrient sensetivity as well - inhibition inhibits mTOR - serotonin and IGF1 raise eachother.

  • Its about the degree of mtor inhibition that rapamycin has. its believed that prolonged Rapamycin use could interfere with mTORC2 signalling which is critical for survival of dopaminergic neurons and proper dopamine signalling. Intranasal rapamycin I don’t have a belief could be detrimental to cognition by interfering with insulin receptor expression. Rapamycin would mitigate many of the detrimental effects from endotoxins and neuroinflammation.

  • It’s insulin transport and insulin sensitivity within the brain that’s important. Excercise forces insulin transport to the brain. Insulin resistance and metabolic disorders are mediated by a degeneration of insulin expressing cells within the brain, with particular importance for the olfactory bulb, and the hypothalamus.

    • endotoxicity, lipotoxicity, neuroinflammation, cortisol, increased opioidergic tone, all promote a degeneration of insulin sensitive gabaergic interneurons which gate sensory function, memory encoding etc.
    • Degeneration of somatostatin inhibitory interneurons and parvalbumin interneurons due to metabolic drift within the brain occurs as a consequence of a high fat diet and neuroinflammation which reduces gabaergic inhibition within the brain that can not be restored by the use of gabaergic drugs.
      • Somatostatin interneurons impart inhibition on parvalbumin gabaergic interneurons, as a result disinhibiting pyramidal cells and decreasing energy cost of neurotransmission.
    • Gaba receptors and interneurons decline in the brain but also increased opioidergic tone, endocannabinoid tone, and endozapine tone reduce the binding affinity of gaba to gaba receptors. Factors such as neuropeptide FF and endozapines compete with endorphins and gaba for their receptors with special importance to somatostatin inhibitory interneurons which coexpress opioid receptors. Increased gabaergic inhibition on somatostatin inhibitory interneurons promotes the internalization of somatostatin receptors and reduces their inhibition on parvalbumin interneurons to promote higher order cognitive functions.
      • The only way that I could see a correction in this decline in somatostatin expression as well as gabaergic interneuron expression within the brain includes blockade of endozapines with flumazenil, blocking gaba receptors with biciculine or a gaba b antagonist, reducing extracellular calcium concentrations with blockade of mu-opioid receptors with naltrexone, increasing the binding of endorphins to opioid receptors with neuropeptide ff antagonists, promoting cholesterol efflux that would otherwise inhibit gaba binding affinity, or promoting insulin sensitivity within the brain with ppary agonists selectively to the brain and katptase activators such as diazoxide.

  • review the literature on iron and multiple sclerosis, parkinsons, alzheimers, huntingtons, and the roles that it plays in senescence and activation of microglia, astrocytes and the dysfunction of neurons and oligodendrocyes. that will be the fastest way to understand iron dysbiosis and cognitive aging

  • Much of our Neurogenesis takes place in the SVZ near the olfactory bulb and these cells migrate outwards as they differentiate into neural progenitor cells and these neural stem cells differentiate into neurons or microglia based on the expression of inflammation in the brain and bdnf/insulin reduce the tone of inflammation and promote cell survival and migration speed through increasing mitochondrial energy supply. Somatostatin 2a is a well known receptor for promoting the migration of neural progenitor cells, and axonal growth.

Quora Chihiro # 

    var interval = setInterval(function() { 
     window.scrollTo(0,document.body.scrollHeight); 
    }, 200);

Then run clearInterval(interval); and then to expand all the posts, run document.querySelectorAll('.qt_read_more').forEach(el => el.click());. Then just Ctrl+P or whatever. Both posts+answers as of 10/14/23 is 2700 pages so that’s just swank.

  • https://www.quora.com/profile/Chihiro-%E5%8D%83%E5%B0%8B-1/posts
    • High IQ and (very much so) Peaty quora poster. Not mega dense though. 305 posts and 431 answers. Dear god.
  • Are these Taiwanese seafarers the most successful hunter-gatherer race?
    • These Hikikomoris are likely foragers in metabolic and endocrine constituency, who are struggling to carve out their place among the spectacle of the commodity market (rat race) that’s coming to define life in Japanese society. Instead, these Hikikomoris surround themselves with books, art, video games, musical instruments, or anything that supplies their life with meaning in a society endlessly occupied with appearances, caught in the transaction of commodities, to which they can dedicate their time to.
    • The Austronesians today are synonymous with virtually every island you can think of. From Hawaii and Polynesia in the Pacific, to the better part of Southeast Asia, to Madagascar in the Indian Ocean, to even the Western stretches of Latin America (which they likely accessed during their Pacific explorations).
  • Ray Peat has repeatedly called Mead Acid the only protective PUFA, and the only one the body needs to manage stress without throttling back respiration.
    • High FADS2>FADS1 = higher Δ6 Desaturase relative to Δ5 Desaturase = more mead acid as opposed to DHA is associated with lower incidence of metabolic syndrome, etc.
      • Well, I have both in terms of genetics. And anyways, You need FADS1 for mead acid synthesis anyways. But maybe it’s not the bottleneck or something, who knows.
      • D6D activity was positively correlated with serum triiodothyronine (R(2) = 0.232; p < 0.001). D5D activity exhibited a strong inverse correlation with serum triiodothyronine
  • Estrogen musings:
    • You lose hedonia.
    • You seek predictability.
    • You become mildly irritable.
    • You begin to see the world as something to be managed impassionately.
    • You seek to consume and not create.
    • You begin hating coffee and meat.
    • You feel heavy, icky.
    • You begin deriving your sense of self through externalisation.
    • You experience violent impulses.
    • You structure your behaviour around compulsion.
    • You begin to see the opposite sex as contrarians.
    • You want results and pay no heed to process.
    • You see things as detached from your being.
    • You seek to compete.
    • You see the world as a gloomy place,
  • Indians have a metallic body odour because of short protein turnover
  • Hyperthyroidism, mongolism, and the great lie of the dietary antioxidant.
    • Mongoloidism (when non-Asians develop monolids) is a sign of nutrient deficiency in a hyperthyroid state? It can happen when you megadose thyroid hormone without nutritional support.
    • East Asians, particularly Siberians, have high capacity for oxidative phsophorylation and have low PUFA genes - long lifespan, high intelligence, low aggression.
      • It’s CO2 from thyroid-stimulated energy metabolism (as opposed to being orchestrated by adrenals/beta-oxidation) protects proteins from being exposed to oxidants.
    • From the usual culprits of estrogens and PUFA to the natural pesticides in plants, only proof of NRF2 or SIRT1 induction is sufficient to assert “antioxidant” status.
  • South Korea: ridiculously low prevalence of hypothyroidism.
  • Ray Peat: “When every cell is functioning optimally, and the organism is adapted to its environment, there is little need for intervention by the “transmitter substances.” … “The first principle of stimulation should be to avoid a harmful activation of the catabolic stress hormones. Light, play, environmental variety and exploratory conversations stimulate the whole organism in an integral way,”
  • “The plasma levels of so-called “cholesterol” (which really refer to an assortment of hepatic lipoproteins that transport cholesterol, fat-soluble vitamins, precious antioxidants like liver-derived CoQ10, among others) have no bearing on the initiation of atherosclerosis. Rather, the amount of “cholesterol” available for the repair of an atherosclerotic lesion, which are caused by nitrosative stress to the endothelium’s mitochondria from NO-producing agents like endotoxin, which produce the signature hypotensive states of septic shock, only speed along or slow down this inevitable degenerative process.”
  • On the level of the whole organism, stress causes overactivity of the pituitary, and removal of the pituitary extends life, and retards the hardening of the extracellular connective material (Everitt, et al., 1983). Several groups (Powers, et al., 2006; Everitt, et al., 1980; Telford, et al., 1986) have shown that removal of the pituitary gland can greatly extend lifespan, if thyroid hormone is supplemented. -Ray Peat
  • The point of meat-eating isn’t to become some sort of big, formidable bully. Rather, it is to cultivate a form of complex intelligence by facilitating a sustained high-energy state, one that doesn’t require external stressors or endocrine responses (hunger, sexual arousal, etc) to guide behaviour .
  • How to build a “master race”?: Get good mtDNA (preferably the M haplogroup, the Siberian G2 and G3 variants) and find ways to enfranchise it with a high steroidogenic capacity.
  • Languages that stimulate the Vagus Nerve < Languages that don’t. The best way to gauge a language’s OxPHOS-friendliness is to place two fingers on your larnyx and speak a couple of sentences at a comfortable pace. Does the larynx spend most of its time at a position lower or higher than at rest? Higher positions indicate more bioenergetic friendliness, or a reduced capacity to cause parasympathetic stimulation.
  • Extroversion is a stress response: Influence of personality traits on plasma levels of cortisol and cholesterol
  • Never falling sick is no measure of immunity. Robust recovery i.e. the ability to spring back to health with little time and effort is. Estrogenic immunosuppressants do a hell of a job keeping you from falling sick, but that’s only because they’re letting the damage accumulate.
  • So unless and otherwise your delivery style is provocative, ridden with sensationalism, you will hardly rouse any energy in the peasant mind to get him to reconsider his positions. Watching the Indian news broadcasts and content creators/influencers should come in as a good exercise in understanding the kind of “stress-inducing” stimuli that a hypothyroid population needs to derive
  • In healthy people running on thyroid hormone, or under a “generative” paradigm, melatonin has adverse effects, interfering with mitochondrial respiration and the use of glucose throughout the night.energy — one needed to re-frame opinions and the likes.
  • Umami = sensing Glutamate concentration in food as a proxy of protein content.
  • Monosodium glutamate and soy sauce are alternate ways of creating the same sensation of “meat”-iness, which bring inviting news to your stomach of an upcoming feast, allowing it to crank up acid production (assisting sertilization of the small intestine too!). Every culture appears to have developed interesting methods of tackling this problem, of making their food taste “meaty” and savourable, giving in to this evolutionary “meat hunger”.
    • The Europeans use dry heat, mainly from barbecues and the like, using heat to degrade proteins just enough to release free glutamate or break down long chains into smaller peptides, whose glutamate terminals can interact similarly with our senses to produce “umami”. While easy to implement, this method risks forming a lot of lipid peroxidation products and protein adducts that you ingest at the end. The Italians, instead, make liberal use of the Tomato for the same purpose.
  • From Wikipedia, on having a conscience: Conscience stands in contrast to elicited emotion or thought due to associations based on immediate sensory perceptions and reflexive responses, as in sympathetic central nervous system responses.
    • The guilt-based culture of the West, vs. the shame-based culture of the East.
  • High Progesterone = higher pheoMelanin content (hence lipstick). Red hair is caused bya complete deletion of a certain Melanocortin Receptor.
  • In irradiated, cultured cells, EuMelanin response is greatly inhibited by Progesterone, and greatly increased by the presence of estrogen.

Serotonin #

  • The high serotonin state or the limbic form of intelligence it facilitates allows blood to be concentrated in the amygdala and surrounding structures (striatum and thalamus), allowing behavioural responses to be pre-meditated i.e. without autonomy, mechanistic, and programmed.

    • This is a really cool way of thinking about psychedelics/LSD and Thalamus disinhibition.

  • A high serotonin state is also an addictive state, where the individual has little choice over what he chooses to do, and as such, high serotonin types are easy to “spoil”. (Buy them some treats two or three times and you can call them your pet dog.)

  • Under a high serotonin state, the striatum is the sole orchestrator of the reward system, where long-term goal-setting, impulse control, and delaying of gratification become next to impossible (functions handled by the dopaminergic circuits of the OFC).

  • Serotonin = vasoconstriction by its very name, so that includes cerebral vasoconstriction.

  • The high serotonin state causes apathy, indifference, and many of the telling signs of depression, but since it progressively narrows the full complexity and range of human experience (as one is no longer experiencing the world but merely reacting to it in a selfish way, guided only by imperatives to either protect oneself or seek opportunity), opportunities for negative experiences are reduced and the functioning within a social system (whether an organization or institution, with well-defined stipulations for punishments and rewards) enhanced.

  • Produces a externalisation” of morality it produces while internally driven by the same selfish desire to “vindicate” or “protect oneself”. This is called a ‘for-better-and-for-worse’ modulation of social behavior, whatever that means: The reciprocal interaction between serotonin and social behaviour

  • Promotes extrinsic motivation like rewards, vs. intrinsic motivation

  • https://www.quora.com/What-is-serotonin-1

    • Serotonin is a monoamine catabolite of tryptophan made during chronic metabolic stress. Serotonin is intimately related to the maintenance of cell energy status (NAD/NADH redox), and its accumulation is associated with bioenergetic failure (low cell energy) and immunosuppression, explaining why it powerfully stimulates cancer, a disease of aberrant metabolism
      • Under catabolic (or metabolically stressful) states, the body liberates large amounts of tryptophan from its stores to facilitate NAD synthesis and rescue bioenergetics. If this doesn’t happen, for whatever reason (such as in the presence of free or non-esterified unsaturated fatty acids), serotonin is synthesized instead and helps lull the metabolism into a torpor-ish state.
    • While promoting a limbic temperament to produce a more aggressive form of sociability (affiliation to superiors and aggression towards subordinates) 15, one that is uncouth and motivated by ignorance and self-interest, serotonin dampens many amicable aspects of social behaviour — such as trust 16, altruism 17, intimacy 18 and playfulness 19.

  • Sleep architecture in the presence of the protective neurosteroids then tends to favour slow brain waves thanks to their activation of the GABA system, which inhibits the serotonin system[3]. (The lack of GABA itself causes people to hallucinate by leaving the serotonergic system unopposed: Reduced occipital GABA in Parkinson disease with visual hallucinations) Dreams do not occur in this state of deep and restorative sleep. It is perhaps this that led Freud (whether he reached this conclusion from a bioenergetics perspective or not) to believe that dreams served to keep a person in rest when sleep was shallow. (I’ve essentially stopped experiencing Dreams in recent months since my metabolism improved.)

    • So if the low-serotonin, OxPHOS-fuelled non-REM sleep is nominal (which is alternatively achievable with GABA-ergic stimulation from the neurosteroids, which has the effect of reducing serotonin and restoring mitochondrial respiration), then we must ask what does the high-serotonin, REM sleep (indicated by diminished levels of neurosteroids) indicate? I think it indicates the body’s attempt to replace the effects of stimulation and brain activity lost to leading a dull life or a low metabolism.

  • I remember one night taking Ondansetron and questioning the need for a police force.

SARS-CoV-2 as a Key Driver of Future Human Evolution & the Upcoming Mass Extinction of the Chromosomally Aberrant Races #

Etc #

  • Olive: ^b86f16

    • Spinach, coconut water, kiwi, berries, lean fish/shellfish, chocolate.
    • I eat 2kg of purple sweet potato (white flesh) (but even purple flesh is low carotene) and snack on fruits (mostly pineapple/tomatoes) and juice (usually cranberry juice/coconut water) through the day. Total carbs come to 600-700g/day, which is a lot but I tend to burn through them pretty quickly - I know this because I test my blood glucose regularly. I think the avoidance of dietary fats while I eat/digest carbohydrates allows me to eat quite a lot without putting on excess weight (look into the randle cycle). I eat carbs during the day while insulin sensitivity is high. And fats four hours after my last carbohydrate meal, which usually means in the night. I feel great and I’m never hungry. Because I eat large amounts of micronutrient dense carbs I can avoid having to rely on supplements. I have 3-4 solid bowel movements a day. Energy is high. Body temp is high, my girlfriend often refers to me as a heater.
    • https://raypeatforum.com/community/threads/steroid-cycle-test-p-masteron-questions-discussion.30220/post-459363 T3 is catabolic. This thread goes into the importance of Estrogen and juicy, controversial things on Steroids/Endocrine System.
    • High carb spares protein requirements. Something like 75 protein, 500 carbs, 10 fat.
    • Daily routine 2 - 7am wake up, 12pm lunch with 3kg sweet potato
    • Bromelain (from Pineapple stem or supplemental) after meals with protein to break down amino acids. Ginger after meals eases digestion/promotes gastric emptying.
    • Sprinkle Glycine (tastes pretty sweet) or sugar over potatoes to increase appetite and take a walk
    • Really high potassium is important on a high-carb diet: 17 mg Potassium per gram of carbohydrate.

  • Mike Fave: I drink pineapple juice, white grape juice, concord grape juice, pomegranate juice, and sometimes lemonade. I also eat alot of chiquita frozen fruit bars including soursop, passion fruit, papaya, tamarind, and guava. Sometimes I also have frozen cherimoya pulp, or frozen mamey pulp. I also eat peaches jarred in sugar and water, and lots of dried persimmon.

    • He can’t touch oranges without adrenaline rushes for some reason. Very strange
    • From what I have read and what I have experimented with there is not need for more than 30-40g of protein in a meal, especially if your younger (max .6-.8g of protein a day). The excess protein just gets oxidized and at that point you might as well eat more carbs or fats.
    • 215 lbs when he was drinking milk over 100-140g fat daily from beef tallow got him to 175-180 @ 10% body fat or less.
      • I dont think saturated fats lead to diabetes at all. I dont worry about the randall cycle or anything like that, especially with my fats being mostly saturated. I dont think the randall cycle is what leads to diabetes in anyway really, especially in my experience
    • Blocking SCD-1 can make fatty liver disease worse by increasing the amount of fully saturated fats at the liver, which are much more difficult to export in the form of triglycerides. It’s moreso about what’s inducing upregulation of SCD and fatty acid synthesis. Endotoxin is his candidate.
    • But I mean, as a structural component—if the liver even needs a significant amount of fat at all?—are they not superior?
    • What I Eat in a Day and More Importantly Why
      • 4 meals a day, each starting with 2 oz of dried pineapple (like 5 or 6 rings) and a cup of grap, cup of pomegranat juice, and 2 oz op passion fruit pulp. Probably to prepare for the incoming protein. All of them have ~40g protein, ~115g carbs, and ~25g fat, while breakfast is fat free.

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