LOX

2023-01-03:

LOX #

• Frankincense is a 5-LOX inhibitor. Not of COX or 12-LOX tho.
• 5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease (2014)
  • LOX-activity.png
• 6 Subtypes:
  • ALOX (Archidonate x-lipoxygenase) includes 5-LOX, 12-LOX, ALOX12B 15-LOX, ALOX15B, and ALOXE3 (epidermis type) and then the uncapitalized mouse genes.
    • 5-LOX converts Arachidonic Acid through a number of subtypes, but then into Leukotriene A4.
    • 5-LOX also metabolizes EPA into subtypes-> Leukotriene A5.
    • AA-eicosanoids.jpeg
    • epa-dpa-dha-eicosanoids.jpg The above 2 pics still aren’t comprehensive.
• Stimulates Superoxide formation?