Fluoxetine

2022-07-06:

Fluoxetine #

• 3α-HSD inhibition = prevents conversion of allopregnanlone to 5α-DHP. Something like that. Congener with Fluvoxamine. SSRI and that’s about it; no significant binding affinity elsewhere. I’ve heard 5-HT2C antagonism, though.
• Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake
  • Title… although they potentiate pentobarbital-induced sedation and exert antiaggressive action. 50x less than pharmeceutical dose, which would ber ~54-270 μg.
• Hippocampal PPAR-α is a novel therapeutic target for depression and mediates the antidepressant actions of fluoxetine in mice
• Chronic Fluoxetine Selectively Upregulates Dopamine D1-Like Receptors in the Hippocampus
  • *We have recently demonstrated that the SSRI fluoxetine can reverse the state of maturation of the adult Dentate Gyrus Granule Cells and enhances serotonin 5-HT4 receptor-mediated synaptic potentiation at the synapses formed by their mossy fiber axons.