PPAR-γ
2022-05-18: reference:
PPAR-γ #
- ‘Master regulator of adipogenesis’; Knockout mice have zero Adipose tissue.
- (tyw says it is supposed to upregulate carbohydrate metabolism)
- Though some studies talk about lipolysis, its net action is promoting lipogenesis.
- Promotes proliferation (as opposed to differentiation into adipocytes) of proadipocytes.
- Promotes M2 Macrophage phenotype.
- Downregulates the GLUT4 promoter when PPAR-γ/RXR-α heterodimer binds to the GLUT4 promoter region.
- Topical agents: Pioglitazone, Magnolol, Telmisartan
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Pioglitazone Treatment Reduces Adipose Tissue Inflammation through Reduction of Mast Cell and Macrophage Number and by Improving Vascularity
- Although there were no changes in total collagen protein, pioglitazone increased the amount of elastin protein in adipose by 6-fold.
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Pioglitazone Treatment Reduces Adipose Tissue Inflammation through Reduction of Mast Cell and Macrophage Number and by Improving Vascularity