Δ6 Desaturase

2022-02-20 links: reference:

Delta 6 Desaturase (D6D) (Linoleoyl-CoA Desaturase) #

• One of the 3 fatty acid desaturases (along with Δ5 and Δ-9), denoting the bond they desaturate (i.e. 6-7, forming an ω-7.)
  • Perhaps among other things, Adipose decreases the amount of Δ5 desaturase.
• Converts:
• cis-Linoleic Acid to GLA - Deficiencies in GLA lead to DGLA PGE1 deficiencies.
  • Palmitic Acid to Sapienic Acid
  • α-linoleic acid to Stearidonic Acid
  • Tetracosatetranoic acid to tetracosapentanoic acid (intedmediate between EPA and DHA)
• Moderation of breastfeeding effects on the IQ by genetic variation in fatty acid metabolism
  • Evidence, in general, is consistent with the hypothesis that LC-PUFAs in breast milk may enhance cognitive development (15).