ALCAR

links: Nootropics reference: 10-31-2021

ALCAR (Acetyl-L-Carnitine) #

• Upregulates D1 without acute dopamine increase or D2 upregulation.
  • Possibly due to the fact it increases BDNF->ERK.
• ALCAR upregulating D1 increases PKA→CREB, which seems meh at first but apparently ALCAR does NOT activate ΔFosB or CDK5! Thus, it’s just CREB->BDNF, TH, etc., and all the good stuff! How the hell?
  • Repeated acetyl-l-carnitine administration increases phospho-Thr34 DARPP-32 levels and antagonizes cocaine-induced increase in Cdk5 and phospho-Thr75 DARPP-32 levels in rat striatum - ’nuff said in title. Persistent after at least 7 days post-treatment as well.
  • Seems legit but it’s potently anti-thyroid, no? It’s not high on the to-do list.

Cholinergic, antioxidant.

• Increases mGluR production in the brain (though not hippocampus).
• Increase Choline Acetyltransferase activity in Striatum/Hippocampus. [R](Stimulation of choline acetyl transferase activity by l- and d-carnitine in brain areas of neonate rats)
• Mitochondrial acetylcarnitine provides acetyl groups for nuclear histone acetylation - basically allows it to oppose the actions of HDAC.
• Effects of Long-term Acetyl-L-carnitine Administration in Rats: I. Increased Dopamine Output in Mesocorticolimbic Areas and Protection toward Acute Stress Exposure
  • 5-HT1A agonist
• TMAO risk

Dose #

• https://old.reddit.com/r/NooTopics/comments/18im0qh/for_me_alcar_is_the_elixir_of_life_in_pill_form/
  • 500mg-2g