Steroid
links: Hormones reference:
Steroid #
https://www.reddit.com/r/sarmssourcetalk/comments/o7fk6m/the_ultimate_nattyunatty_stack_with_a_twist/ “The functions of cholesterol parallel the functions of other sterols in plants and other types of organism. Its functions have been refined and extended with the development of other steroids, such as progesterone, as biological requirements have evolved, but cholesterol is still at the center of this system. To deliberately interfere with its synthesis, as contemporary medicine does, reveals a terrible arrogance.” - Ray Peat
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Along with thyroid hormones, they circulate in the bloodstream attached to plasma proteins.
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Synthesis of steranes is unique to eukaryotes and can be used as a biomarker of their presence.
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As lipids, they act intracellularly, binding to receptor proteins.
- This mediates target cell response, actiating genes, stimulating synthesis of whatever proteins or causing cell proliferation.
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Most nonpolar steroids are absorbed topically. With each hydroxyl and ketone group, it becomes more polar and less penetrable.
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Androgens inhibit MAO in the Pineal Gland, leading to increased Melatonin and reduced Luteinizing Hormone and FSH - via melatonin-induced increase of gonadotropin-inhibitory hormone synthesis/secretion.
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Dissolving steroids in DMSO yields superior bioavailability to even subcutaneous administration, like a good 3x better in some cases.
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Half life in the blood is usually 30-60 minutes, but in the case of hormones this is more like its onset, since it stays in the tissues for hours.
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Multiple Roles for Sphingolipids in Steroid Hormone Biosynthesis