Parkin
2022-12-08:
Parkin #
- E3 ubiquitin ligase. Translocates defective mitochondria for their clearance->mitophagy when ΔΨ decreases.
- Activation requires phosphorylation of Ser65 by PINK1 (PTEN-induced kinase 1).
- Impairment is seen in Parkinson’s - go figure.