SNARE

2022-05-05: reference:

• Calcium Control of Neurotransmitter Release (2012)
• Molecular mechanisms of neurotransmitter release

SNARE #

• SNARE = SNAP REceptor = SNAP-25, syntaxin (t-SNARE?), Synaptobrevin. I think that’s it besides the subtypes; Synaptotagmin isn’t a SNARE proper and merely associates with the complex
  • SNAP-25 aka VAMP (vesicle-associated membrane protein)

500interesting how it depicts membrane constituents mixing as it progresses…

• The intitial sensor is Synaptotagmin, and it becomes activated after 4-5 Ca2+ bind: 360
• Syntaxin and SNAP-25 are the cell membrane. At the vesicle membrane, synaptobrevin and Synaptotagmin, which binds Ca2+.
• Omega-3 polyunsaturated fatty acids promote SNAREs mediated GLUT4 vesicle docking and fusion

SNAP-8 (Acetyl Glutamyl Heptapeptide-1) #

Derived from Argireline (Acetyl hexapeptide-3 aka -8). It mimicks a fraction of SNAP-25 and renders it dysfunctional. These peptides reduce the depth of wrinkles caused by facial movements via com

• Topical application for atrophic scars. SSA sells it.
  • Compare with botox, which blocks different SNARE proteins including SNAP-25 depending on the subtype Successful Topical Application of Botulinum Toxin After Microneedling Versus Microneedling Alone for the Treatment of Atrophic Post Acne Scars: A Prospective, Split-face, Controlled Study