5-HT3
links: reference: 10-4-2021
5-HT3 #
- Ionotropic! It’s actually basically just a nAChR via DNA and structure. As far as subunits go:
- Rodents do not even express 5-HT3C/D/E. Causes nausea, ickiness, depression, anxiety, and poor memory.
- Ginger antagonizes it
- Found on (presynaptic) neurons where they have an inhibitory effect on acetylcholine release.
- [Serotonin 3 Receptor Blockade is Involved in Vortioxetine -Induced Prevention of Anxiety/Depression Relapse Phenotype]
- Schizophrenia, sensory gating, and nicotinic receptors
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Selective 5HT3 antagonists and sensory processing: a systematic review
- Odansetron reverses sensory gating deficits and improves visuoperceptual processing in animal models of psychosis.
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Brain Lipids and Disorders in Biological Psychiatry
- In Schizophrenia, the response to successive auditory clicks are similar. Whereas in normal subjects the second click elicits ~20% the response.
- P50 is the potential 50ms following the click.
- Excess Phospholipase A2 in schizophrenia?
- α7 nAChR is able to inhibit PLA2.
- The development of an ELISA for group IVA phospholipase A2 in human red blood cells
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Brain Lipids and Disorders in Biological Psychiatry
- Odansetron reverses sensory gating deficits and improves visuoperceptual processing in animal models of psychosis.
- 5-HT3 antagonists have numerous side effects, the most prominent of which being prolongation of the QT-interval, the interval between contraction and relaxation of the heart. Progesterone attenuates this: R. Also headache.