SIRT1
10-17-2021 links: HDAC reference:
Sirtuin 1 (NAD-dependent deacetylase sirtuin 1) #
WNT signaling blocks its degradation, I guess.
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Its role is to deacetylate PGC-1α
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Increases Fatty Acid Oxidation one way or another. SIRT1 andor Resveratrol can reliably induce Cancer.
- [SIRT1 plays key role in chronic myeloid leukemia by aiding persistence of leukemic stem cells]
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Charles Brenner, NR guy on twitter: SIRT1 is cope and resveratrol doubly so
- The insiders at Sirtris, however, sold these compounds & this research program to @GSK for $720 m. Imagine how they felt when the fly, worm, mouse & chemical data they were sold were shown to be deeply flawed & irreproducible.
- SIRT2 hype was failed to be reproduced: == Absence of effects of Sir2 over-expression on lifespan in C. elegans and Drosophila==
- Valter Longo: Sir2 Blocks Extreme Life-Span Extension
- Brenner: Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+
- WTF? SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1
- The epicenter of dysregulation of HFD mice is liver NADPH. Nicotinamide Riboside supplementation has mice resist weight gain from HFD. Apparently just coincidentally, SIRT1/SIRT3 are elevated here.