9-Me-BC

links: Nootropics reference: 10-20-2021

9-Me-BC (9-methyl-β-Carboline) #

• Regenerates Dopamine neurons and increases sensitivity to stimulants.
• Upregulates Tyrosine Hydroxylase transcription factors like CREB.
• Increases Neurotrophic Factors
• Reduces Lactate Dehydrogenase, inflammation, etc.
• DYRK1A (Dual specificity tyrosine-phosphorylation-regulated kinase 1A) inhibitor
• Do not mix with methyl donors?
• Controversy around it being toxic/carcinogenic. It is indeed photosensitive/‘phototoxic’. Take it in the winter because apparently skin DNA damage could be a thing?? It’s caustic to the teeth as well and burns to swallow.
  • JC (and Uxküll I believe) says it’s been debunked
  • It does at least transiently increase photosensitivity, but it’s also genoprotective and shouldn’t cause melanoma due to its anti-cancer effects
• MAO-B inhibitor, but it’s not really relevant at dosages used.

• 10mg/mL 300mg solution is $40 on science.bio. Not exactly cheap
• Uxkull does 2mg daily for month. Science.bio sublingually.
• JC recommends 30mg buccal. Needs a few weeks for full affects. Keep it under your tongue for 5-10 minutes then probably do the swish tactic
• Umbrella: $81 for 1g