yana-notes

Progesterone

4-11-2021 links: Hormones Steroid Neurosteroid reference:

Progesterone (P4) #

  • We produce 5% as much in old age than we do in our youth - Up until the mid-teens, males and females produce equal amounts. RPF

  • The youngest siblings tend to be the smartest due to higher progesterone concentrations. The golden age is apparently early thirties. Lifespan is also increased in proportion to number of pregnancies.

  • Inhibits lactation during pregnancy. Plays a role in alveolar differentiation on breast tissue.

  • "…testosterone can be produced by immature rat testicular microsomes from added progesterone on an organized unit without the intermediates equilibrating with the incubation medium" RPF

  • “If you are easily aroused, have an intense experience and a quick refractory period afterwards, it is generally a good sign. If the libido is high but the sexual experience is generally “flat” and unsatisfying (leading to frustration and more “seeking” of it), that could be a sign of elevated estrogen. Progesterone is known to improve sexual health/performance in both men and women…”

  • Faces of men with high serum testosterone are less attractive for women during the fertility phase of the menstrual cycle

  • It has a high affinity for 5-AR, more so than many other steroids. Thus, in very high doses it can increase Allopregnanolone, and less DHT. But in physiological doses, it can increase it, since 5a-DHP->allopregnanolone->androsterone->DHT. RPF“If taken in large amounts it antagonizes the effects of testosterone.” ~Peat

  • Progesterone inhibits Estrogen by converting Estradiol into the less active forms, Estrone and Estriol, and by decreasing expression of ERα and ERβ, and reduces ER-dependent ranscriptional activity as a result. Conversely, excess estrogen opposes progesterone.

  • Progesterone isn’t directly aromatizable, but it can convert into 17-hydroxyprogesterone, into androstenedione, and into estrone/estradiol.

  • Antagonizes Aldosterone

  • Lowers Luteinizing Hormone pulse frequency in large doses RPF

  • https://raypeatforum.com/community/threads/dhea-progesterone-pro-anabolic-testosterone-promoting.29905/post-445561

    • Progesterone blocks muscle catabolism better than testosterone due to it being a better antagonist of the Glucocorticoid receptor, which are actually expressed more than androgen receptors in muscle tissue. Truly anabolic steroids also obviously agonize AR, along with antagonizing GR. Haidut makes the case that when it comes to building muscle mass, GR antagonism is much more important than AR, for the latter is mostly expressed in the prostate, gonads, brain, skin, whatever - not muscle tissue. RPF
    • Structural Requirements For An Optimal Anti-Catablic Steroid

  • Can lead to hypermobility RPF

  • Prenatal Progesterone and Educational Attainments (Katharina Dalton, 1969-2018)

  • Progesterone treatment induces the accumulation of both GLUT1 and GLUT3 transports in neonatal rats.

  • Decreases 5-HT1A binding in the Amygdala and Orbitofrontal Cortex. R

  • Increases GABA and MAO

  • Has anti-Serotonin actions

  • Upregulates CB1.

  • [Progestin‐induced hermaphroditism: IQ and psychosexual identity in a study of ten girls]

6-Ketoprogesterone (6-keto P4) #

Gyno #

  • Fixes gyno in some people, causes it in others. Usually, the latter, it seems. I think it’s because of estrogen detox. The question is how much should you take before you finally reach Ray Peat nirvana, and all the estrogen is gone? Carrot salad will accelerate the detox process.
  • People seem to say that it doesn’t directly cause gyno, but it helps out whatever estrogen is present. This makes it a little complicated, considering it does ‘inhibit estrogen’. But maybe it doesn’t at the breast tissue?

Supplementation #

  • Peat recommends taking 3 drops 5x/day (52mg) for the first 10 days (some people on RPF recommend 100mg+ for just a few days), and then on to physiological doses, which would be <10mg… people (both men and women) report taking 20mg for anabolism, or way larger amounts, and feel great.

  • On idealabs: Progestene: Progesterone 20mg (12 drops)

  • Progest-E. I think this is the best stuff to take orally. https://www.longnaturalhealth.com/Dr-Peats-Progest-E-Complex-34-ml. Some people take it orally and rub it on the gums (clear mouth of saliva and drop over tongue; it tastes bitter) some people just take it topically, which has 10-15% absorption ( https://raypeatforum.com/community/threads/dhea-progesterone-pro-anabolic-testosterone-promoting.29905/post-584576)

    • “Start with just a couple of drops.” A drop has about 3.5mg. People tend to split the doses, but the best time is night, since it can knock you out.

  • “MALE” PROGESTERONE? “No. Pregnenolone as a first thing and then DHEA if you need a more androgenic thing the pregnenolone will push your neural steroids the crucial regulating things that you don’t want to throw out of balance. With a strong androgen like DHT that would be one a big risk that you could have throw off your neuro steroids.”

  • Haidut’s bodybuilder friend supplemented a 11:1 ratio of progesterone:DHEA (3:1 is common for non-athletes in the Peat circle) and it made him feel like he was on 75mg of testosterone. Okay, then. Haidut’s Pansterone has 5mg of pregnenolone and 5mg DHEA per 4 drops.

  • Made a guy feel drunk. https://raypeatforum.com/community/threads/dhea-progesterone-pro-anabolic-testosterone-promoting.29905/post-445865

  • I’m not sure why people make the addition of supplementing DHEA with progesterone. It restores the libido, I assume by allowing more DHT to be synthesized.

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