Aspirin

links: reference:

• https://www.stlukes-stl.com/health-content/medicine/33/000196.htm
• https://www.youtube.com/watch?v=CS9ygUEQ3E8
• Aspirin Comparable To DNP As Mitochondrial Uncoupler (RPF)
• Amelioration of Sleep Apnea by Salicylate-induced Hyperventilation
• Nonsteroidal Anti-Inflammatory Drugs Affect Normal Sleep Patterns in Humans 4-11-2021

Aspirin (Acetylsalicylic acid) #

• As an NSAID, it is a anti-Histamine, but this may deplete DAO, as well as iron, B9, C, and sodium.
• Lowers fibrosis. Inhibitor of Phospholipase A2. Exerts inhibitor effects on the induction of cirrhosis caused by choline-deficient diet.
• I’ve read it inhibits Δ6 Desaturase? According to olive or something
• Neuroprotective; it can reduce cerebral White Matter lesion (WML). Can promote oligodendrogenesis and Oligodendrocyte myelination after WML.
• An effective antiseptic for the intestine. It usually absorbs early in the digestive track, unless mixed with fat. Specifically, it usually absorbs in the stomach or small intestine. If mixed with fat, it could make it to the colon. Gut
• Can improve Sleep. First try it in the afternoon, as it can stimulate your metaboilism, and therefore delay sleep. Try 500mg at night or something, if not. This is possibly due to its anti-Histamine properties.
• Memory-enhancing effect of aspirin is mediated through opioid system modulation in an AlCl3-induced neurotoxicity mouse model
  • Downregulates δ-Opioid Receptor
• Aspirin and platelets: the antiplatelet action of aspirin and its role in thrombosis treatment and prophylaxis
  • Acetylates Platelet COX at Ser529, preventing Arachidonic Acid from accessing the cattalytic site of the enzyme at Tyr385.
  • 100-150-fold more potent at inhibiting COX-1 than COX-2.
  • There are no known prostaglandin-independent mechanisms for the antithrombotic action of aspirin in clinical use.
    • Thus, platelet activation caused by other factors remains unchanged and might result in a resistance against inhibition of platelet function by aspirin. This involves platelet activation by shear stress and ADP.
• https://twitter.com/LandsharkRides/status/1725566772483444975 high doses making your eyes brighter genuinely might wor

White Willow Bark #

• About 3x the dose of aspirin is required for raising serum salicylic acid.
• Stronger analgesic. Antioxidant. Activates NRF2. While it contains salicin, that’s not. Apparently has none of the side effects like GI damage or blood thining.
• 2.4-9.7mg/kg slowed brain serotonin turnover.
• In vitro anti-proliferative effects of the willow bark extract STW 33-I
• STW 33-1 and its fraction E increased the COX-1 mRNA expression.

Supplementation #

Anywhere between 150-1200mg @ 10-25% salicin. Sweet spot more like 300-900.

Interactions #

• Lowers stress hormones, Aromatase, excess free fatty acids, inflammatory mediators, Parathyroid Hormone, Glutamate, Nitric Oxide, Aldosterone, and Temperature. Peat (Moro et al., 2000)
• Antagonizes PGD2 (by 86%) - “When combined with Vitamin E, aspirin-dependent inhibition of prostaglandin E2 formation was increased from 59% to 95% of control” RPF - This lasts for 10 days or so! RPF
• Lowers Serotonin release from platelets R. 400mg/kg increased Serotonin content in brain but significantly decreased the number of cortical 5-HT2 receptors. R
• Inhibits (excess) Lipolysis
• Low-Dose Aspirin Upregulates Tyrosine Hydroxylase and Increases Dopamine Production in Dopaminergic Neurons
  • A53T transgenic mice treated with 2mg/kg (HED for me like 11mg)
  • https://raypeatforum.com/community/threads/low-dose-aspirin-upregulates-tyrosine-hydroxylase-and-increases-dopamine-production.25527/
• Increases CO2 and cAMP; Aspirin increases Glucose Oxidation (by inhibiting that of fatty acids) R
• Inhibits PI3K-AKT-mTOR pathway

Aspirin and Human Sleep (Horne et al., 1980) #

• Soldatos et al: Nighttime doses of 650 or 1300 sodium salicylamide to insomniacs; Hauri and Silberfarb: 650mg to aspirin to insomniacs. Only significant finding from either study was a reduction in interim wakefulness during sleep.
• Slowing of the waking EEG has been reported following a single 1g dose of aspirin.
• Its effect on sleep can be owed in part to prostaglandin inhibition.
• 1800mg doses significantly elevate serum free Tryptophan!
  • Due to a release from its binding site on serum albumin. R: urinary excretion of 3-hydroxyanthranilic acid is decreased, that of xanthurenic acid is increased, and that of 3-Hydroxykynurenine (3HK) was increased.
    • On another note, aspirin (15mM) somewhat inhibits the active transport of L-tryptophan across the small intestine. R

Supplementation #

• $13 for pure 60g powder https://healthnatura.com/aspirin-powder-usp-60g/

• https://raypeatforum.com/community/threads/topical-absorption-of-caffeine-aspirin-and-niacinamide.5847/post-90098

  • 21% topical absorption on ethanol.
  • Having low absorption isn’t a big deal since the half-life is much longer.

• Mixing aspirin + caffeine increases availability? (This is the basis of ECA - ephedrine, caffeine, aspirin)

  • Clearly, ephedrine is the star of the show as β agonism is ultimately thermogenic, as well as anorectic. Aspirin’s role is to prolong this via inhibition of prostaglandin. Together with caffeine it also keeps cAMP(-> thermogenesis) high.
  • Ephedrine: VMAT2 inhibitor
  • ECA is something like 72mg ephedrine, 600 mg caffeine, 80mg aspirin.

• Should not be taken as a pill, because it can get stuck in the mucosal walls and produce local damage.

• Should be taken with food, dissolved in water, and strained through a filter.

  • Dissolve in hot water is best. OJ doesn’t decrease bioavailability by much but milk seems to be like -20%. R
    • This article is actually pretty informative and measures several parameters for the salicylate metabolism. Looks like a good read.

• Taking 325mg every third day is very similar to 81mg every day.

  • https://raypeatforum.com/community/threads/so-aspirin-stops-breast-cancer-but-does-it-reverse-gyno.12003/post-179551
  • This is a good protocol, since the gut mucosa needs to adapt to aspirin, and infrequent dosing will only make it more stressful, I think. Over time, it will strengthen the GI though, according to haidut.
    • Does not affect intestinal permeability. RPF