mGluR5
2022-12-03:
mGluR5 #
- Gq
- Upregulated in astrocytes by Aβ
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Reduced astrocytic mGluR5 in the hippocampus is associated with stress-induced depressive-like behaviors in mice
- mGluR5 is higher in mice resilient to psychological stress = longer therapeutic window to recontextualize/prevent fear consolidation.
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Inhibition of the ISR abrogates mGluR5-dependent long-term depression and spatial memory deficits in a rat model of Alzheimer’s disease ISRIB
- Increasing eIF2α phosphorylation, the core event of ISR, facilitates metabotropic glutamate receptor (mGluR)-dependent long-term depression (LTD),
- mGluR5 hypofunction is integral to glutamatergic dysregulation in schizophrenia
- mGluR5 Allosteric Modulation Promotes Neurorecovery in a 6-OHDA-Toxicant Model of Parkinson’s Disease