yana-notes

Hair Loss

links: reference: Saving my progress: https://raypeatforum.com/community/threads/hair-loss-thinktank-passionate-and-or-intellectual-people.40689/page-4 - https://raypeatforum.com/community/threads/hair-loss-thinktank-passionate-and-or-intellectual-people.40689/post-649987

Hair Loss #

“The hair follicle itself is a complicated mini-organ that stands to be negatively affected by even subtle shifts in the efficiency with which energy is generated. In fact, because of the already inherent inefficiency of metabolism present therein, the hair follicle is one of the most sensitive among all the organs to these shifts.”

    • DPC = dermal papilla; HFSC = hair follicle stem cell
  • Apparently hair anywhere besides the legs is estrogen driven - estrogen irritating the adrenals leading to higher peripheral DHEA->androgens leading to hair growth.
  • Hamilton’s castrates/psuedohermaphrodites had reduced oily secretions from sebaceous glands and minimal to no dandruff.
  • Associated with arterial stiffness and metabolic resistance. Risk for hyperinsulinaemia and cardiovascular disease.
  • In cases of MPB, there can be up to 4x normal amounts of Mast Cell in the scalp.
    • Mast cells increase PGD2, not PGE2… or does PGD2 activate mast cells?
  • Sebaceous cell hyperplasia
    • Thematic review series: skin lipids. Sebaceous gland lipids: friend or foe?
      • They claim that respectively low/high Wnt/c-Myc/Hedgehog leads to hair follicle vs sebaceous gland differentiation from epithelial progenitor cells:
        • Mice with mutations in β-catenin, which decrease Wnt signaling through a binding defect in β-catenin, have an increased number of sebaceous glands over normal mice (sounds like the opposite of the above claim)
        • c-Myc is downstream of β-catenin and overexpression = increase in sebaceous gland size/number (proliferation) and decrease in number of hair follicles.
  • Nizoral is pretty meh compared to purer ketoconazole products. Racosinate = carcinogenic; sulfate = irritation, etc.; benzyl alcohol = dryness. It’s also kind of just a meme considering the short time frame is spends on your scalp

Anatomy #

900 The red tissue holding it is the arrector pili muscle, which conencts the dermal surface and the follicle and contraction (piloerection) causes goose bumps.

  • Fibroblasts tell keratinocytes when to divide and induce repeated growth and are a signaling center for follicular stem cells, which decline with age, thus reducing the number of fibroblasts.

Growth Cycle #

Hormonal Profile #

Prolactin #

DHT #

Treatment #

Protocol #

  • My kitchen sink topical would be something like a water-soluble bottle and another lipid-soluble bottle of the following:
    • 0.2% caffeine
    • Melatonin
    • DKK inhibitors: Niacinamide, threonic acid
      • Basically everything in the placode serum besides the acrylates/polymers
    • WNT/β-catenin inducers:
      • Those mentioned in Choi et al above (Ginseng, caffeoyl compounds, and the other weird stuff)
      • Redensyl
    • TWIST inhibitors:
    • Bioenergetics: Solban, Caffeoylquinic Acid (again)
    • PGE2 inducers like castor oil? Salicylic acid might remove this from the picture though.
    • Phytoceramides/phyto stem cells?
    • SkQ1?
    • Sirsadalot vouches carnosic acid (in PEG400, got up to 100mg/mL) + idebenone for preventing dandruff (put it in head and shouylders)
    • Progesterone for paracrine prolactin inhibition? Could be risky.

  • Bryan Johnson’s NEW protocol: #

  • Bryan Johnson’s OLD Protocol 1mL applied daily
    • Caffeine USP 1%
    • Finasteride USP 0.25% (thus 2.5mg. In reality 0.2 (0.25% 100μl, or 0.025% 1 mL) is an ideal low range if I were to try this)
    • Minoxidil USP 5% (I go over this there kinda)
    • Azelaic Acid 1.5%
    • Diclofenac 0.5%
      • COX-2 inhibitor.
      • Holy shit, all NSAIDs are SULT inhibitors.
    • Tea Tree Oil 5%
    • Rosemary Oil 0.37% (so 3.7mg)
    • Ginko Biloba 0.05%
    • Biotin 0.01%
    • Melatonin USP 0.0033%
    • All dissolved in Trichosol, which is a hydrophillic solution thing. The carrier is honestly very important, or else there may not be a lot stopping it from going systemic
      • Other pharmeceutical preparations of minoxidil and such around the world use this as a solvent as well. So if I wanted to get my hands on this stuff I’d probably look for a minox product. Supposedly not the best for post-application look compared to foam>hydroalcoholic as a close second.
  • He also does + PRP, dutasteride mesotherapy, autologous exosomes, laser cap
  • Throw in Carnosic Acid (which I just realized is the primary component of rosemary) and the other stuff in Neotopical

Novel Chemicals #

Microneedling #

  • 1200-1600 needle strikes per cm². 1mm, however 1.5mm dermaroller is fair since it doesn’t penetrate as deeply as the motorized devices. Once every week, maybe once every 2 weeks.
  • Either wait a few hours after minox to microneedle (bad idea if you’re using peppermint oil, and so I assume rosemary as well.)
  • … or you can apply all your topicals the morning after (probably the better option if you’re using topical dut because fuck that, but if weekly I’d microneedle the night after weekly dut day)
  • … or just skip a minox(+dut) dose and only do minox 6 days a week. So like dut on sunday and microneedle on monday night or something.

Peptides/Serums #

I actually ought to look up clinical trials for some of these formulations like Redensyl, because they may be legit for regrowth

  • RevivserumsThis (discontinued!) peptide hair serum has:
    • Oligopeptide-54: promotes growth & revitalization of follicles and circulation
    • Decapeptide-10: a DKK-1 inhibitor
    • Decapeptide-18: similar to WNT10
    • Additionally contains niacinamide, caffeine, B5, and PEG 20/23 dimethicone, acrylate crosspolymer, sodium acrylaates copolymer & lecithin, triethanolamine, fragrance.
    • They have dozens of formulations for various skin, hair, and nails conditions.
    • This is the new one, the hair stimulating serum, which has:
      • 5.0% Redensyl (this paper goes very in-depth)
        • Contains dihydroquercetin-glucoside (DHQG). Polyphenol which stabilizes fibrillar collagen forms and inhibits melanogenesis. Activates follicle stem cell division, activates Bcl-2 (inhibits apoptosis) and WNT
          • Also an agonist of AdipoR2 and opioid receptors.
        • EGCG2: General antioxidant and cytokine reducer
        • Glycine, zinc chloride, meta-bisulfite, glycerin.
        • Do not store at temperatures over 10°C?? (50°F)
      • 1.50% Capixy®
        • Acetyl tetrapeptide-3 (probably safe) mixed with red clover extract, which is rich in biochanin A, a 5-ARi.
      • 3.0% Procapil®
        • Consists of Biotinyl-GHK, apigenin, oleanolic acid (a 5-ARi).
      • Keratinocyte growth factor
      • Myristoyl pentapeptide-17 (keratin stimulating)
      • GHK
      • And mothafuckin’ phyto stem cells: PhytoCellTec Malus Domestica, PhytoCellTec Argan, Celtosome Crithmum Maritum, Anasensyl
      • Caffeine, soy isoflavones, grape seed proanthocyanidins, horse chestnut
      • Nettle root and saw palmetto. GOT EM!
  • Stemoxidine (Diethyl Lutidinate; Mexoryl) patented by L’Oreal in 2012. P4H inhibitor; induces hypoxia in stem cells, raising oxygen levels at the layer near the skin surface, lengthening the kenogen phase.
  • Sepicontrol A5: 5AR inhibitor.

Hair Transplant #

  • 2023-10-31
  • Don’t cheap out on the surgeon, since apparently there’s quite a bit you can get wrong? Like angulation of the grafts, for one thing.
  • FUE (follicular extraction unit) is omst likely the only thing I’m doing. Have heard good things about FUT (where they cut a whole strip) though. https://www.youtube.com/watch?v=t8wOzgVGYz4. Apparently FUE is overmarketed because it has a better scar position as if it matters.
    • With FUE there’s minimal to no minimal shaving required (though traditionally yes, and I think it’s the cheaper and easier option), as is the case with FUT.
    • In Istanbul, a hair transplant costs like $1000-$3150 (and then consider the ~$1000 2-way flight). Price per graph is maybe $0.7 or so. But some clinics don’t actually charge extra for more graphs apparently. Also, they basically do whatever you ask, so voila, just do your research.
  • Shock loss: I think it’s relatively uncommon for regular tranplants, like 5-10%. It happens both in the donor and transplant area.
    • One reason is due to traumatization of existing hair follicles in the area, including surrounding native areas.
    • Can occur even 3 months after.
  • Lng hair FUE is the real deal where donor grafts, length and all, are transplanted. Thing is, it can completey fuck you with shock loss and all the length is lost a few weeks after the operation (so it’s over). Not sure if we’ll ever get past that.W what’s the point, lol?
  • Erdogan is one of the best surgeons in the world for it
  • Haircafe says hair transplants last forever, and that blüdflow and scalp tension theory is bullshit, which is kind of whitepilled honestly, since that means it’s all down to genetic determinism (and donor dominance), which is more easily changeable in the grand scheme of things with drugs and whatnot.

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