WNT

2022-02-19 links: reference:

WNT (“Wingless-type”) signaling pathway #

• Canonical pathway:
  • Also see
• Wnt/Ca2+ pathway: Gq?->Phospholipase C -> etc. -> NFAT, CREB
• JNK pathway: DV1 -> RhoA->ROCK and Rac1->JNK->TGF-β
  • Since ROCK is a negative regulator of PTEN (and IRS-1) this is anti-mtor
• WNT1->WISP1->PI3K->AKT->…

In humans, there exists WNT1-16, with some subtypes all the while.

• WNT10A/B are implicated in oncogenesis. B is implicated in adipogenesis, coronary vessel formation, and attenuating pathological fibrosis.

• WNT4 implicated in very high Intelligence.

  • Growing evidence suggests that downregulation of Wnt signaling could be involved in the cognitive decline associated with aging and also with the physiopathology of Alzheimer’s disease (AD). R

• Reduces Fibroblast proliferation, probably through antagonizing TGF

• Distinct functions for Wnt/β-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis (Choi et al., 2014)

  • By inducibly deleting β-Catenin globally in skin epithelia, only in hair follicle stem cells, or only in interfollicular epidermis, and comparing the phenotypes with those caused by ectopic expression of the Wnt/β-catenin inhibitor Dkk1, we show that this pathway is necessary for hair follicle stem cell proliferation
  • β-Catenin is not required within hair follicle stem cells for their maintenance, and follicles resume proliferating after removal of ectopic Dkk1, indicating persistence of functional progenitors.

• CELLULAR DEMISE AND INFLAMMATORY MICROGLIAL ACTIVATION DURING β-AMYLOID TOXICITY ARE GOVERNED BY WNT1 AND CANONICAL SIGNALING PATHWAYS

• Wnt pathway in chondrogenesis http://www.heightquest.com/2010/08/wnt-pathway-in-chondrogenesis.html