Luteinizing Hormone

Produced by gonadotropic cells in anterior Pituitary Gland, in response to Gonadotropin-releasing Hormone from the hypothalamus.
- Signals endocrine cells in the gonads to produce androgens. In men: leydig cells. It binds to LH receptors, causing an increase in cAMP, activating StAR.
Acts synergistically with FSH to produce sperm from test and ABP (androgen binding protein).
Both LH and FSH are secreted in pulses, so measuring blood level should be at specific times.
Stimulates 3β-HSD and 17β-HSD. This is significant, since taking roids and getting shut down will mean their pathways are used less.
- https://en.wikipedia.org/wiki/Luteinizing_hormone
- https://men-elite.com/2020/01/08/how-to-interpret-your-testosterone-blood-test-results-in-order-to-focus-on-whats-most-important/
Cortisol, estradiol, inflammation, and other obvious bullshit can possibly inhibit the testes from responding to LH.
Very high levels could indicate that the pituitary is overstimulated and that the Hypothalamus is not sensing the elvated testosterone, or that DHT or estrogen are really low, since estrogen is the most pontent inhibitor of LH secretion, followed by DHT.
Low testosterone and elevated LH and normal/high estrogen is hypogonadism.
Should be low, so long as testosterone is high.

yana-notes