Carnosic Acid

2022-12-30:

Carnosic Acid #

• Anti-androgenic in prostate cancer cells, but no normal, heatlhy cells. Sounds pretty genius for things like DHT in prostate cancer and whatnot.
  • Carnosic acid promotes degradation of the androgen receptor and is regulated by the unfolded protein response pathway in vitro and in vivo
    • Binds the ligand-binding domain of the AR and degrades the AR via endoplasmic reticulum (ER) stress-mediated proteasomal degradative pathway
• *From helping insomniacs avoid harmful sedating drugs like ambien, to potentially saving brenden’s sister’s life when she was fighting a bacterial infection, to helping psoriasis, to helping people with anxiety, to literally working counter to the aging process and warding off cancerous cells in support of healthy cells - Not to mention various studies pointing to it having a possible future in neuroprotection in the case of dementia-like conditions, post TBI cognitive function and more
• Might be worth it topically, liposomally. Swiss thought about doing this also with Gotu Kola in the formulation.
• Lowers noradrenaline
• Rosemary extract is very rich in it. But rosemary also has lots of anti-androgens, thyroid inhibitors, and other estrogenic constituents.
• Prevention of 4-hydroxynonenal-induced lipolytic activation by carnosic acid is related to the induction of glutathione S-transferase in 3T3-L1 adipocytes
  • Reduced 4-HNE mediated FFA release.
  • Reversed phosphorylation of IRS-1 Tyr-632 and Ser307.
• https://supplementsinreview.com/nootropic/rosemary-nootropic/
  • Rosmarinic acid and carnosic acid are both AchEi.
    • Molecular interaction of acetylcholinesterase with carnosic acid derivatives: a neuroinformatics study
    • Sounds great for the sleep improvement, no??
  • Cognition enhancing effect of rosemary (Rosmarinus officinalis L.) in lab animal studies: a systematic review and meta-analysis
• Carnosic Acid Reverses the Inhibition of ApoE4 on Cell Surface Level of ApoER2 and Reelin Signaling Pathway
  • ApoE4 attenuates the binding of sorting nexin 17 (SNX17) to ApoER2 and inhibits the recycling of ApoER2, resulting in decreased cell surface level of ApoER2.
  • counteracts the negative effects of ApoE4 on the cell surface level of ApoER2 to reverse the ApoE4-induced reduction in Reelin signaling activation by increasing the phosphorylation of the NMDAR and CREB, and the expression of GluR2.
• Serotonergic?

Dose #

• 250-500 mg.
• Like 20 nootopics anecdotes of it being sedating and great for sleep (most of the prominent members like Bonk or whoever).
• Good topically as an antioxidant. cf. rosemary oil extract like https://gardenofwisdom.com/collections/miscellaneous-ingredients/products/rosemary-oil-extract-5?_pos=1&_sid=00630caf1&_ss=r#. Unfortunately though it’s not water-soluble. Adding it to my moisturizer might be good, since they have emulsifying agents and whatnot.