EGCG

2022-02-23: reference:

EGCG (EpigalloCatechin Gallate) #

GABA-A modlulator and antioxidant. Poor oral absorption and high doses (800mg?) have potential liver toxicity.

• Found in teas and a few plants.
• Extremely powerful COMT inhibitor, moreso than pharmaceuticals for that purpose, which can also be liver-damaging.
• (-)-Epigallocatethin-3-O-gallate counteracts caffeine-induced hyperactivity: evidence of dopaminergic blockade
• [The crystal structure of the green tea polyphenol (−)-epigallocatechin gallate–transthyretin complex reveals a novel binding site distinct from the thyroxine binding site]