Pyrilutamide

2024-11-27:

Pyrilutamide (KX-826) #

• Topical androgen receptor antagonist. Stronger than RU.
  • Less likely to go systemic than RU due to higher molecular weight, and much lower dose.
• Thing about AR antagonists is that upregulation is possible. Also, things could get even worse when coming off. Simple 5ARis don’t have this
• It’s actually coming out in cosmetics on Amazon and shit
• Kintor kinda failed their phase III with it. Thing is, that’s for full reveral. For just halting it, it might still be promising.
• Way higher binding affinity than RU

Dose #

• ~30mg/day for serious potency. People do like 10mg

• 0.5% is $69/month for Koshine Biomedica (a subsidiary of Kintor… bruh) brand on Amazon. They just got it approved as a cosmetic since at least it’s confirmed safe at least. They pretty much moved on from it and are onto GT now
• https://umbrellalabs.is/shop/research-chemicals/kx-826-liquid 30mL of 5% solution for $100. So you would use 200μl tops undiluted. It’s in “plant-based liquid”. 500mg of powder for $120
  • Anageninc also has stuff in that vein
• 1% for $200, wtf? https://main.m.taobao.com/security-h5-detail/home?id=827522640728&skuId=5720053194158&fromNormal=true doesn’t look like a lot either
• 60mL of 0.5% for $105. https://www.minoxidilmax.com/pyrilutamide-solution-pyripure