GHK

2022-02-23: Peptide Skin reference: Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data

GHK (glycyl-L-histidyl-L-lysine) #

Naturally occuring, and it declines with age.

• Seems it’s mostly used as GHK-Cu, a Copper tripeptide form:

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• Compared to control, GHK-Cu treatment on wounds showed lower levels of TNF-α and Metalloproteinases. R. In diabetic rats, showed faster wound healing and higher glutathione and ascorbic acid levels, increases synthesis of collagen and activation of Fibroblasts and Mast Cell R

  • This means you gotta start taking more zinc!!

• Decreased TNF-α dependent IL-6 secretion in fibroblasts R.

• Stimulates keratinocyte proliferation, increased expression of Integrins and p63 in epidermal stem cells. R

• ESI-MS study of the mechanism of glycyl-l-histidyl-l-lysine-Cu(II) complex transport through model membrane of stratum corneum

  • Stimulates synthesis of Collagen and Elastin and ’extracellular cement’. It’s really a kitchen sink.
  • *Permeation of an exogenous substance through skin layer is a passive diffusion process that depends on a large number of different factors [15] and can be described by Fick’s first law of diffusion [16].
  • The pH of the surface is 4.2-5.6, but the lowest layers of the epidermis are at 7.4. Copper ions precipitate as hydroxide in solutions less acidic than ~4.0.