Minoxidil

2023-01-27:

Ruins collagen formation (bloating, wrinkles, eye bags, etc.) Also exists orally.
Promotes water retention; like pounds.
Actually a pro-drug for minoxidil sulfate, which requires SULTA1 for conversion, hence the Tretinoin tactic. You can mix them together, like in a shot glass. Use gel.
Noone is sure what its MOA even is:
- New Target for Minoxidil in the Treatment of Androgenetic Alopecia (2023) in vitro.
  - Suppresses Androgen Receptor expression and 17α-Hydroxylase expression. Induces Aromatase (locally).
- Induces expression of PGE2, VEGF, HIF-1α

Once daily is just as effective as twice daily according to haircafe
Ideally applied 1 day after microneedling according to the studies out there
Shedding can last a good 3 months tbh. Kevin Mann says it’s not true anything will get any ‘worse than before’ if you were to quit.
Exponentially increasing effects until ~6%.
Half-life is 22 hours so skipping a day isn’t that big a deal
For excessive hair growth in weird locations,

Btw, it became OTC in 1996

Micktak uses stuff from Minoxidilmax but throws in 2% rosemary oil, 2% peppermint oil, carnosic acid, 1-2% ketoconazole
- Sirsadalot says peppermint oil is cytotoxic and relies on antioxidants to not kill the scalp
The propylene glycol in most solutions causes skin drying. But I really don’t know if it absorbs well without it. It’s glycerin-based and also has dimethyl isosorbide to enhance solubility and delivery. Minoxidil doesn’t dissolve in water very well.
https://www.minoxidilmax.com/dualgen-5-fast-dry 1mL to be applied daily, so it’s a 2 month supply for $30, EZ.
- Minoxidil 5%, Azelaic 5%, ABN 0.8, retinol 0.025, caffeine 0.001%.
- Time to add melatonin 0.003, 0.025% finasteride, and caffeine 0.199
- The no-PG stuff is supposedly super glue-like on your hair

yana-notes