Mast Cell

links: reference: 6-6-2021

Mast Cells #

Accounts for up to 90% of Brain Histamine in rats, but the number of cells ranges from zero to thousands in all species; mast cells migrate.

• Hypothyroidism can cause an increase in number of mast cells R
• Zinc inhibits degredation
• In the brain, they are the first responders to inflammation: Suppression of Brain Mast Cells Degranulation Inhibits Microglial Activation and Central Nervous System Inflammation
  • Interestingly, a mast cell stabilizer inhibited MAPK/AKT. And of course inhibited H1, H4, TLR4.
• Its preformed granules contain not only histamine, but also 5-HT, lysosomal hydrolases: like β-Hexosaminidase, proteases: like tryptase, chymase, carboxypeptidase. It also releases prostaglandins/Leukotriene, and inflammmatory mediators.