Vitamin K2

2022-04-17: reference:

• In this post is a metric fuckton of references for the benefits of K2

Vitamin K2 (Methaquinone/Menaquinone) #

• In a word, D enhances calcium absorption, and K2 enhances its usage in bones and cells.
• Activates protein S RPF
• 45mg of vitamin K2 caused, in several cases, permanent and spontaneous remission of last stage liver Cancer. RPF
• K2 and other quinones inhibit MAO-B RPF
• Inhibits Lipid Peroxidation R and Prostaglandin synthesis R

Calcium/Physiology #

• Significantly reduces arterial stiffness by reducing blood calcium levels.

  • The dark side of course is when Ca is inadequate, it can increase Prolactin and Parathyroid Hormone! This could explain some people blaming it for Hair Loss. RPF

• Requirement rises with increased consumption of Vitamin A and Vitamin D. "Vitamin D upregulates the expression of certain proteins that must be activated by the vitamin K-dependent process of carboxylation; when the level of these proteins exceeds that which the pool of available vitamin K has the capacity to carboxylate, this pool becomes depleted."

• Prevents removal of calcium from bone from things like Parathyroid Hormone and PGE2 that increase the bones’ Lactic Acid production.

• The Medical Benefits of Vitamin K2 on Calcium-Related Disorders

  • Absorbed via Enterocytes in the small intestine, aided by the presence of Bile and pancreatic secretions.
  • The kidneys are also stimulated by Parathyroid Hormone to secrete Vitamin D!
  • Vascular calcification is due to a lack of activation of inhibitory proteins that prevent mineralization of the vessels, that being Hydroxyapatite. These inhibitory proteins? Vitamin-K dependent (VKDPs).
    • Vitamin K1 does not have much of an effect, since LDLs don’t transport them nearly as much.
  • Its benefits in the testes are also due to its enhancement of calcium uptake into them.

Steroids #

• https://raypeatforum.com/community/threads/raising-serum-androgens-using-dhea-pregnenolone-and-vitamin-k.13505/#post-186762

• https://raypeatforum.com/community/threads/gonadin-liquid-steroid-optimizer-for-lab-r-d.15620/post-212509

  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180407/

• https://raypeatforum.com/community/threads/kuinone-liquid-vitamin-k2-mk-4.9169/

  • Fuckton of other virtues.

• K2 (only MK-4) increases StAR by increasing protein kinase A signaling. Also increases CYP11A activity/expression.

  • K2 does not alter Luteinizing Hormone, so this mechanism acts independently of it.
  • Amazoniac calls it menakillone-4

• Stimulates formation of Osteocalcin and Osteonectin.

• (MK-4) is a potent Aromatase inhibitor and decreases Estradiol and PGE2 R

• K2 binds to 17β-HSD, converting Estradiol to Estrone R

In rats and testis-derived tumor cells.

• It seems the Geranylgeraniol (GGOH) is one of the reasons behind this. Using just GGOH, testosterone was increased in about the same concentration.
  • It also boosted progesterone synthesis. This is a good reason to apply to the gonads.

Supplementation #

• 10-45 mg per day according to some people.

  • BEWARE! “Taking 30mg in a single dose gave me the most intense insomnia, agitation, and sweating I have ever experienced.”
    • https://raypeatforum.com/community/threads/kuinone-liquid-vitamin-k2-mk-4.9169/post-134570

• Take apart from vitamin E

• Take at night? It can make you really drowsy.

  • https://raypeatforum.com/community/threads/kuinone-liquid-vitamin-k2-mk-4.9169/post-124613
  • https://raypeatforum.com/community/threads/kuinone-liquid-vitamin-k2-mk-4.9169/post-124614

• Melts into a waxy blob in the heat.

Danny Roddy uses Thorne though?

• Thorne K2: $69 $55 $44? 1200x K2 MK-4 1mg (1,200mg total = 16mg/day = 75 days/bottle)

  • Solvent: Mixed tocopherols and MCT oil.

• Haidut’s Kuinone: $50 - 750x2mg (16mg/day = 93 days/bottle)

  • Solvent: SFA esters + anhydrol (ethanol). Apparently it’s just as good as the old DMSO formulation.
  • About 80% absorbs in the first hour; the 20% slowly for the next 23.
  • 3-5x as effective as oral supplements, i.e Thorne.

• HealthNatura - $50 1200mg in MCT

• powder $25 or $20/g https://www.trafarx.com/index.php?main_page=product_info&products_id=812