Vitamin D

links: Vitamins & Minerals reference:

• https://raypeatforum.com/community/threads/increased-activation-of-vitamin-d-1-25d-25d-ratio-is-likely-to-be-linked-to-disruption-of-the-bone-kidney-parathyroid-endocrine-axis.44115/
• https://raypeatforum.com/community/threads/is-vitamin-d-supplementation-even-neccessary.23844/ Amazoniac doing what he does best. Good to look into. He calls it Venom D.
• Supraphysiological doses of vitamin D changes brainwave activity patterns in rats RPF 4-12-2021

Vitamin D #

In its active form, calicitrol, it is a Steroid. Do not supplement calcitrol (which is rare) - you want cholecalciferol. The proper test is for 25(OH)vitamin D. The suffcient amount is that which lowers PTH, which is around 40-100ng/mL. Toxicity begins at 150.

• Main UV source is UVB (290-315).

• Regulates the intestinal absorption of Calcium, Magnesium, and Phosphate.

• Reduces intestinal uptake of Vitamin E and Vitamin K. Keep in mind that simultaneous topical application may not interfere with eachother at all. Haidut says vitamin D works best only in cominbation with K. RPF R

• Vitamin D: A custodian of cell signalling stability in health and disease

• Amazoniac does not seem to be a fan of vitamin D? He’s spammed the Calcirol page with controversial research about/against it. Worth looking into. RPF

• This whole thread is banter https://raypeatforum.com/community/threads/be-wary-of-vitamin-d-supplementation.26022/post-379687

• https://raypeatforum.com/community/threads/why-you-shouldnt-supplement-vitamin-d.36672/

• Supplementation raised serum levels of Selenium and magnesium in type 2 diabetics. R

• Deficiency correlated with hyperparathyroidism. Parathyroid Hormone RPF

• Increases the effectivity of coadministered Steroids. RPF

• Fat is not required for it to be bioavailable RPF

Physiology #

• After calcitrol binding, the Vitamin D Receptor heterodimerizes with RXR.

Supplementation #

• Thorne’s Liquid D3: $15 9.75? - 1200x500IU (600k) (61,538 iu/$)
  • Solvent: Medium-chain triglyceride oil, mixed tocopherols
• Haidut’s Calcirol: $25 - 240x1000 IU (240k) (9,600 iu/$)
  • Solvent: SFA esters + anhydrol (ethanol)
    • Due to this, Haidut says it most likely has much better absorption than oil-dissolved supplements, like thorne’s. It’s like 2.5x more expensive, but 50-60% absorption as opposed to ~10-20% is not unreasonabl. R
• Premier Research Labs
• NOW foods D3: $7.75 - 750x1,000 IU (750k) (96,774)
  • Solvent: MCT from coconut/palm kernel
• SeekingHealth D3: $20 - 900x2,000 IU (1.8m) (90k)
  • Solvent: Olive oil
• Nature’s Answer: $18 - 480x1,000 IU (480k) (26.66)
  • Solvent: EVOO
• HealthNatura: $27 - 1330x5,000 IU (246,295 IU/$)
  • Solvent: MCT
• https://nutrasal.com/products/copy-of-microd3-sub-micron-nano-vitamin-d3-with-k-and-trace-minerals $17 - 240x1250 (300k) = 17k IU/$ except it has meme liposomal absorption technology or whatever