MAO
links: Enzyme reference: 4-16-2021
MAO #
- Located on the outer mitochondrial membrane.
It is a large source of Hydrogen Peroxide.
MAO-A degades all amines.
MAO-A can safely metabolize a lot of what MAO-B can, but not vice versa.? - JC says that all monoamines should be used/raised in tandem, and this is kinda reflected in the fact MAO degrades all 3.
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Redefining differential roles of MAO-A in dopamine degradation and MAO-B in tonic GABA synthesiis
- They aim to investigate the effects of A on this (nigrostriatal) tonic GABAergic inhibition that B has come to be characterized by.
- We demonstrate that MAO-A, but not MAO-B, mainly contributes to striatal dopamine degradation. In contrast, our whole-cell patch-clamp results demonstrated that MAO-B, but not MAO-A, was responsible for astrocytic GABA-mediated tonic inhibitory currents in the rat striatum.
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Changes in cyclooxygenase activity and prostaglandin profiles during monoamine metabolism in rat brain homogenates
- Lead to the induction of COX