DHT

links: Hormones Steroid reference:

DHT #

A paracrine steroid - it is synthesized in peripheral tissues as needed, as opposed to having high circulating amounts in the blood stream.
DHT upregulates Androgen Receptor synthesis and reduces turnover, and has something like 4-10x testosterone’s affinity. R
Dihydrotestosterone activates the MAPK pathway and modulates maximum isometric force through the EGF receptor in isolated intact mouse skeletal muscle fibres: Increased fast twitch isometric force by 30% after incubation of isolated rat myofibers with 630pg/ml DHT. It decreased slow twitch by 20% though?
A negative correlation in 110 young men between DHT:testosterone ratio and hair loss. R. There was an association between hair loss and a high free T:total T ratio, since unbound T is what actually gets reduced in the scalp.
Just a 2-page writeup on DHT: No correlation between serum correlations and AGA or acne. R
Increases respiratory quotient (RQ) and decreases Fatty Acid Oxidation. It reudces overall oxygen consumption without affecting CO2 production. R
Production is dramatically increased when hyperThyroid.

DHT burns up NO needed to make VEGF which feeds hair follices?
https://men-elite.com/2019/08/01/dht-for-a-dry-lean-and-androgenic-physique/
- Promotes apoptosis of Adipose cells.
- Increases eNOS
- High doses (like 70mg) lowers testosterone production significantly. It synergizes with Testosterone to produce muscle and burn fat, but test is more important, since it is the primary active androgen in muscle.
  - Excess DHT overpowers the effects of test - low sex drive, anxiety, etc.
- Increases protein synthesis and transport of amino acids into fast contracting muscle fibre bundles, whereas testosterone does not.
  - Boosts muscle strength to a greater degree than testosterone.
- Prevents Adrenocortocotropic Hormone increase in response to stress.
Reduces lipid accumulation and cholesterol synthesis via increasing expression of Carnitine Palmitoyltransferase 1 and phosphorylation of 3-hydroxy-3-methyl-glutarly-CoA reductase.
Inhibits Aromatase R:
High doses suppress 17β-HSD3, but I think this might just be via Luteinizing Hormone.
DHT competes with Estradiol for binding (as a reverse agonist) to the cytosolic Estrogen Receptor
DHT - How it Affects the Brain - And Nervous System
- Increases brain GABA activity, CNS adrenaline and cAMP, T4->T3 Conversion, Decreases Glutamate levels and excitotory outputs

Intracellular concentrations of androgens are essentially independent of circulating levels.
Elevated DHT has not been associated with increased risk of prostate disease distinct in any ways distinct from T.
“DHT does not play a substantive role in body composition compared to T under normal conditions. Thus, elevated levels of DHT in response to TRT are unlikely to appreciably impact lean or fat mass. Nonetheless, data from animals suggest a role for DHT in Adipose that inhibits biochemical pathways involved in lipid synthesis and promotes several transcripts associated with apoptosis of Adipocytes.”
- Both T and DHT have been shown to inhibit preadipocyte proliferation and Adipocyte differentiation and to stimulate Lipolysis, and dose-dependent inhibitory effects on lipoprotein lipase activity in adipose tissue.
Very limited data on DHT and cognition
In the eugonadal state, AR stabilization is driven by Testosterone more than DHT.
Upregulates certain inflammatory cytokines in Acne (IL-1, IL-6, etc.), and like other androgens increases sebum, though a unique role has not been demonstrated. R
DHT and E2 are correlated with increased Telomere length.

53 minute terminal half life, or 2.83 terminal half life. But in tissues is another story.
Up to 20-25mg daily is basically the physiological limit, which are tricky to calculate, but it’s ~8mg before there’s suppression. ~1mg is produced from T each day, but it can be produced via the androgen backdoor pathway as well, and higher rates of endogenous synthesis from prerequisites are possible.
Effects of 10 Days Administration of Percutaneous Dihydrotestosterone on the Pituitary-Testicular Axis in Normal Men
- 125mg 2x/day for 10 days in 12 normal men. (@ 10% absorption this is 25mg.)
- T decreased from 733ng/dl to 133, E2 from 46 to 20 pg/ml, and LH from 7.8 to 4.2 mIU/ml. DHT went from 52 ng/ml to a peak of 534ng/dl.
- A study used 80mg of DHT (gel, I’m assuming? Thus ~8mg systemically) and found no suppression of HPGA. RPF

https://raypeatforum.com/community/threads/need-help-dissolving-dht.22718/ 2022-01-07 (just rambling/vlogging) 2021-12-18 -> 2021-12-20 Benzyl alcohol is a better solvent and would be drying but would probably aid with the irritation.

Straight powder in DMSO is probably the best bet as long as it isn’t irritating.

Andractim is 80mL/80g, 2.5% DHT = (2g for $118 - not a disaster compared to PPL if it’s all you need)

2 men aged 45 & 43. 175mg DHT-hp in seasame oil intramuscular.
4 boys 14-16. 200mg DHT-hp in seasame oil intramuscular. Then, 150μg GnRH. Then, 300mg every 3 weeks 5x.
- I’d wager that 2 days after clearance is a little too soon to see ‘return to baseline’.

3 months of daily 70mg DHT in 0.7% hydroalcoholic gel in men >60 years with T < 432.
Blood drawn 2x before, 3x during (1 month apart), and 1 month after.
(1nmolL = 28.818ng/dl)
- The good news here is that everything went back to normal 1 month after treatment ended, besides very miniscule decreases in LH, FSH, SHBG, and a miniscule increase in E2. I’m assuming this is an auspicious sign considering the average age of the DHT group was 71.
- Changes were a reduction of ~60% T, ~60% LH, ~25-30% FSH.
- “The decrease in plasma SHBG over time in both groups (but unrelated to DHT treatment) is consistent with the lack of effect of DHT in the short term”
- Shredded brah!

Group 1: gnRH-deicient men. LH levels measured every 15 mins.