5-HT1A
links: Neuroreceptors reference: 5-16-2021
5-HT1A #
Ligand-gated receptor.
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It is either a somatodendritic autoreceptor (which inhibits the release, not just picks it up), such as in the Dorsal Raphe Nucleus, or it’s postsynaptic, in areas like the hippcampus and cortex.
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Influence of Serotonin on the Blood–Brain and the Blood–Spinal Cord Barriers
- *In patients of Alzheimer’s disease, the density of 5-HT1A in the Hippocampus is decreased together with loss of the pyramidal cells (Cross et al., 1988).
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Influence of Serotonin on the Blood–Brain and the Blood–Spinal Cord Barriers
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- Thus, the desensitization of somatodendritic 5-HT1A autoreceptors in the dorsal and median raphe following chronic SSRI treatment appears to be due to a reduced capacity of the 5-HT1A receptor to activate G protein. By contrast, no significant change in postsynaptic 5-HT1A receptor-stimulated 35SGTPγS binding was observed in any of the forebrain areas examined following chronic antidepressant treatment.
- Thus, changes in postsynaptic 5-HT1A receptor-mediated responses reported to follow chronic SSRI or tricyclic antidepressant administration most likely occur distal to receptor-G protein interaction, perhaps at the level of effector, or involving changes in neuronal function at the system or circuit level.
- Administration of kainic acid into the hippocampus induces a selective degeneration of pyramidal cells and interneurons, causing loss of a 5-HT1a binding site (Hall et al., 1985). These observations suggest that 5-HT1a receptors are mainly postsynaptic.*
- Thus, the desensitization of somatodendritic 5-HT1A autoreceptors in the dorsal and median raphe following chronic SSRI treatment appears to be due to a reduced capacity of the 5-HT1A receptor to activate G protein. By contrast, no significant change in postsynaptic 5-HT1A receptor-stimulated 35SGTPγS binding was observed in any of the forebrain areas examined following chronic antidepressant treatment.
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Single treatment with 1A agonists reduce the extracellular Serotonin concentrations in the rat midbrain and forebrain. R
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Anti-aggressive, can stimulate appetite. Hypothermic.
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Reduces GABA and serotonin release R and synergizes with μ-Opioid Receptor R. Stimulates release of Oxytocin.