Magnesium

Magnesium #

Magnesium is required to convert B1 to its active form. As thiamine is a cofactor for magnesium, high doses of magnesium can lower thiamine, and vice versa. Take the two together.
Oral absorption can be quite low. It’s fat soluble, by the way.
Synergistic uptake with B6.
Increases 17β-HSD
Synergizes with Vitamin D, which drastically increases requirements for magnesium.
Decreases Aromatase activity.

Enhancement of Learning and Memory by Elevating Brain Magnesium (not done - looks good)
- higher density of synaptophysin-/Synaptobrevin-positive puncta in Dentate Gyrus and CA1… correlated with memory improvement. Upregulation of NR2B
- Increased the number of functional presynaptic release sites, while it reduced their release probability.
Elevation of Brain Magnesium Potentiates Neural Stem Cell Proliferation in the Hippocampus of Young and Aged Mice
Targeting the NMDA receptor subunit NR2B for treating or preventing age-related memory decline (2014)
- Magtein elevated brain magnesium levels which upregulates NR2B.
- (Forebrain) Upregulating the NR2B subunits in the forebrain regions leads to a longer NMDA receptor channel opening duration and larger peak amplitude… accompanied by a remarkable enhancement of LTP but no changes in LTD, as well as enhanced learning and memory function.
Enhances CREB activation from NMDAR, even in the absence of extracellular calcium. Inhibiting p38 or chelating magnesium influx prevented this. R

Food sources include cocoa, coffee, spinach, kale, oats, molasses.
Shoot for >=200mg/day.
Do you even need to take it everyday? Other stuff it’s synergistic with probably do, so you might as well.
Low bioavailability != low elemental magnesium. You hve to take both into consideration.
It seems a good stack is threonate in the morning, micromag at night, for stimulation and sedation respectively.

Magnesium L-pidolate (8.664% w/w.) is the salt of L-pyroglutamic acid. Haidut claims that its presence in the DMSO makes it a lot less irritating and without drying/peeling, and it absorbs in 20 minutes (it’s an absorption enhancer, too) leaving the skin smooth. 30mL of liquid.
- Haidut says 1 drop = ~25mg of DMSO. Calculator says 25mg = 0.02mL; 50 drops for 1mL of DMSO. 1 drop also has 13.3mg of magnesium.
  - They just got from a database that DMSO is 1.1014g/cm^2. Just unit conversion after that.
750 drops for $30. 1 drop ~=13.3mg, so 15 drops = 200mg, which lasts 50 days. 20 drops = 270mg, which lasts 37 days.

65% elemental and 20% absorption… so 2g becomes something like 250.

Tastes horrible like oversweetened metal. 14% elemental magnesium.

400-800mg.

No taste. Costly, but causes no irritation

Might make you stimulated, not sleepy. People on ND say it’s a good nootropic, due to it crossing the BBB and containing Threonic Acid. Probably a better option than micromag if you’re not deficient.
Only like 7% elemental magnesium: Assuming 300mg from diet, take 4g for 280.
- 4g daily (280mg) @ $60 120g = $2/day; 30 days
Acetylcholinesterase inhibitor

Insoluble in water. Tastes way better than glycinate and is very easy on the intestine.
Nootropicsdepot: $35 90x625 (56.2g) https://nootropicsdepot.com/micromag-novel-highly-bioavailable-magnesium-supplement/
32-38% elemental magnesium! Encased in a sucrosome structure to increase bioavailability and reduce GI discomfort.
- Thus, assuming 300 from diet, you only need like 300mg. = 900mg scoop = 33 days; 0.6/day
A sucrester is a curose ester of a fatty acid. Very easily absorbed into cells, especially M cells, found in the intestine.
Probably makes you sleepy compared to threonate. A review said high doses made him stimulated.

Can cause explosive diarrhea. Simple as

Trash it. Has notoriously poor absorption. By weight, it has much more elemental magnesium compared to some other forms, so it can work?