CA1

2022-03-04: Hippocampus reference:

• http://neuronbank.org/wiki/index.php/CA1_pyramidal_neuron:

CA1 #

• A single CA1 Pyramidal Neuron has ~30,0000 excitatory and ~1700 inhibitory inputs of Glutamate/GABA. R

• What is its role in the trisynaptic circuit?:

  • http://scholarpedia.org/article/Models_of_hippocampus
    • Some models have proposed that region CA1 functions as a comparator of the input from entorhinal cortex layer III with the output from region CA3 (Gray, 1982; Hasselmo and Schnell, 1994; Hasselmo and Wyble, 1997).
      • This comparator function was used to set the levels of acetylcholine to modulate the dynamics of encoding and retrieval in a simulation of region CA1 (Hasselmo and Schnell, 1994) and in a network simulation of hippocampal memory function (Hasselmo and Wyble, 1997).
        • Laminar selectivity of the cholinergic suppression of synaptic transmission in rat hippocampal region CA1: computational modeling and brain slice physiology (Hasselmo & Schnell, 1994)
        • Free recall and recognition in a network model of the hippocampus: simulating effects of scopolamine on human memory function (Hasselmo & Wyble, 1997)
          • This goes DEEP on the experiment and how it relates to every part of the circuitry. Crazy how it’s human.
        • Ayo, is this describing @Nicotinic Acetylcholine Receptors Control Encoding and Retrieval of Associative Recognition Memory through Plasticity in the Medial Prefrontal Cortex? Different acetlycholine levels giving emergence to whatever physiological differences dictate α7 vs. α4β2?