B6

links: Vitamins & Minerals P5P reference: 4-12-2021

B6 #

• Exists as Pyridoxine, Pyridoxal, Pyridoxamine, and their phosphorylated derivatives: pyridoxine 5’-phosphate, P5P (highest biological activity) and pyridoxamine 5’-phosphate.

• Pyridoxine hydrochloride increases activity of 5-AR, while pyridoxal hydrochloride inhibits it. Pyridoxine is plant B6, pyridoxal animal. The former can worsen B6 metabolism.

• Needs are increased along with Dietary Protein.

• Essential for the synthesis of Dopamine; inhibits Prolactin RPF

• Long-term supplementation has cured ADHD. R

• Can inhibit Cortisol secretion and receptor sensitivity.

• An excess in B6 can reduce androgen receptor sensitivty?

• The vitamin B6 paradox: Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function

  • Not P5P, mind you.
  • Increased BAX and Caspase-8 activity.

Supplementation #

• Can inhibit biosynthesis of B1. R . Deficiency increases intestinal uptake of zinc. Increases Folate requirements. Chronic and acute deficiency increases intestinal uptake of Zinc while serum levels decrease. High levels may increase zinc requirement [R]( https://pubmed.ncbi.nlm.nih.gov/1957821/, https://pubmed.ncbi.nlm.nih.gov/7137956/). Synergizes uptake with Magnesium, and retention of magnesium.