Acetylcholinesterase
links: reference: 10-18-2021
Acetylcholinesterase (AChE) #
- Don’t forget about the other cholinesterase, butyrylcholinesterase (synthetic). Dual cholinesterase inhibitors work on both of these.
- Non-fearful rats have a ton of this stuff, and AChE-KO mice have increased Depression an anxiety-like behavior.
Inhibitors #
- So I think they differ a lot - especially with herbals, which usually produce AChEis as a toxic defense mechanism. They could have different binding affinities for certain regions, which is obviously pretty relevant.
- Inhibitors cause Gyno through unknown mechanisms.
- Scopolamine and datura are pretty potent AChE inhibitors, raising ACh levels in the brain, but their strong antimuscarinic properties far overshadows this.