p38
20022-04-19: reference:
p38 MAPK #
They respond to physically-cellularly stressful stimuli like osmotic shock and oxidative stress.
- Linked to NMDA-evoked Prostaglandin release. But it’s just linked to excessive NMDA activation via MAPKK.
- [Astrocytic p38α MAPK drives NMDA receptor-dependent long-term depression and modulates long-term memory]
- LTD induction enhances astrocyte-to-neuron communication mediated by glutamate, and that Ca2+ signaling and SNARE-dependent vesicular release from the astrocyte are required for LTD expression… low-frequency astrocytic activation, in the absence of presynaptic activity, is sufficient to induce postsynaptic AMPA receptor removal and LTD expression
- Removal of astrocytic (but not neuronal) p38α abolishes LTD expression.
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p38 MAP kinase-mediated NMDA receptor-dependent suppression of hippocampal hypersynchronicity in a mouse model of Alzheimer’s disease
- Amyloid β induces ‘hypersynchronicity’, and so does p38.