Sigma Receptor
links: reference: https://en.wikipedia.org/wiki/Sigma_receptor https://en.wikipedia.org/wiki/Neurosteroid 4-30-2021
Sigma Receptor #
σ1 and σ2. It induces hypertonia, tachyardia, tachypnea (respiratory), and mydriasis (pupil dilation), and possible euphoria.
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Hella ligands, including DMT, Cocaine, DXM, Methamphetamine, Methylphenidate, fluvoxamine, fluoxetine (Prozac), ketamine, Memantine, Berberine, and other random shit. Selegiline binds to σ1 @ 400 nM affinity, Neurosteroids, Testosterone
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Antagonized by Progesterone, Sertraline, etc.
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Activation releases Acetylcholine.
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Postsynaptically increases NMDAR currents, I reckon R