σ1

2022-04-16: reference: https://www.reddit.com/r/prefrontal/comments/18wwbas/the_neuroscience_of_sigma1_%CF%831_and_its_relevance/

σ1 #

• Located on the endoplasmic reticulum where it modulates IP3 receptor’s calcium signaling.

• Heteromerizes with D2.

• Upregulaes AADC and TH. A ‘chaperone protein’ of the Smooth Endoplasmic Reticulum, co-localizing with their Inositol Triphosphate receptors.

• The sigma-1 receptor as key common factor in cocaine and food-seeking behaviors

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    • Ghrelin-R1a-D1 heteromers…. damn.

• Hypothesis: The Psychedelic Ayahuasca Heals Traumatic Memories via a Sigma 1 Receptor-Mediated Epigenetic-Mnemonic Process

  • Ayahuasca, via hyperactivation of trauma and emotional memory-related centres, and via its concomitant SIGMAR1- and MAOIs- induced anti-amnesic effects, facilitates the retrieval of traumatic memories, in turn making them labile (destabilised). As Ayahuasca alkaloids enhance synaptic plasticity, increase neurogenesis and boost dopaminergic neurotransmission, and those processes are involved in memory reconsolidation and fear extinction, the fear response triggered by the memory can be reprogramed and/or extinguished.
  • σ1 mobilizes synaptic receptors and boosts plasticity.
  • Anti-amnesic by activating cholinergic and NMDA neurons.
  • The calcium-sensitive Sigma-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction