yana-notes

Memantine

links: Nootropics reference: @Memantine a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system - too little activation is bad, too much is even worse (Parsons et al. 2007) 10-5-2021

Memantine 100 #

Dose #

Well, it’s sold in 5, 10, 20 mg tablets.

  • 20 mg+ is definitely psychoactive, but it’s nothing super debilitating yet.
    • I think the visuals you get from low doses are from antinicotinic action
  • 30 mg causes modest visuals and bodily sensations begin to manifest. Some of the body sensations I find are permanent. Luckily not the paresthesia. That was uncomfortable. for example I still feel like I have wings from time to time.
  • 100mg+ is when dissociative effects kick in.

~70 hour half life. Indeed, if you trip, you’re gonna be waking up feeling pretty similar. High doses can have an afterglow that makes the experience last a week bro.

  • Countless people on reddit advise against long-term use, but do advise to dose for 1-4 weeks for steady-state concentrations to be reached. Permatolerance is also bound to happen if taken daily for long enough.
    • People also recommend titrating up in ~5 mg increments, even if you plan on tripping and stuff.

Anecdotes #

VeganPermanently #
  • low dose (>1mg) is worthless acutely, but after a few days and more so a week it starts to become procognitive and even more importantly, it is incredibly antidepressant in a way similar to psychedelics (it makes you actually solve the problems in your life not just forget about them like SSRIs) and a strong stimulant. very low dose (1mg) has some procognitive effects acutely but it’s limited.
    • At 1-3mg daily, cognition is worsened for the first week then it gradually gets better and improves beyond baseline over time At 2 week mark you’ll feel like a robot, hyperfocus on any task you’re doing and task switching will also be effortless. The higher the initial dose, the faster the adaptations, which is why I start at 30 mg and work my way down in 5 mg decrements per week to my preferred dose which is 15-20 mg.
    • At the very low dose (1 mg) Memantine causes cognitive enhancement acutely. Anything above 3-10 mg produces acute cognitive dysfunction and visuals, after a week this turns into cognitive enhancement. Presumably, through alpha 7 nicotinic sensitization. With Armodafinil this turns into profound enhancement of working memory and executive
    • https://old.reddit.com/r/MemantineHCl/comments/17w38cn/memantine_has_different_effects_across_dose/
      • 15-30: There are also many sensory side effects, most worryingly intense vertigo and fingertip paresthesia (much more unpleasant than it sounds). Time becomes insanely valuable, everything is an urgency. Strong ergogenic effects also present, strength is increased, endurance becomes unlimited. Need for sleep is decreased if not entirely non existent and sleep quality is ruined, dreams are non existent. Anything above 20 mg is acutely hard to handle, anxiety and dysphoria may present, but these disappear around T+6.
  • Tolerance is the sought after effect which potentiates the Armoda in this combo. I don’t know what happens, literature isn’t helpful either. NR2B seems to downregulate from chronic Memantine which is probably a negative outcome I’m countering with low dose D-Aspartate (upregulates the receptor). My hypothesis is that chronic Memantine upregulates α7 and this is the cause of the improvement in cognition and stimulant potentiation but I didn’t find any studies to either support or disprove this hypothesis.
    • Memantine doesn’t work on its own for him, apparently.
    • Regarding Memes&Modes I start from 30 mg then taper 5 mg each week to target dose which is for me 15-25 mg (15 works seldom and 25 has side effects, 20 is the sweet spot).
      • The reason I like the 30 mg more than lower doses is bcs it allows me to be fully functional albeit with a bit of working memory dysruption but the Alpha7 receptors upregulate much faster than at lower doses and it becomes nootropic after 3 days, at 7 day mark it’s fully effective. I’ve found the dose can be reduced once this happens, but it’s not effective below 15-20 mg.
      • At 30 mg/day it increases dopamine in the PFC to the point I become a deity. By deity I mean I have full control over my actions, inactions, reactions. I am no longer addicted to any disruptive behavior I usually can’t shake off
  • Improves lateral thinking to a great degree. Potentiated by armodafinil
  • Higher doses were fun and improved my depression immensely but it seems I developed a permanent tolerance to those effects from therapeutic dosing (20 mg/d). It seems these effects are caused by alpha 7 nicotinic antagonism and permanently cancelled by upregulation.
  • Potentiates MDMA
  • https://old.reddit.com/r/researchchemicals/comments/1567c9f/is_memantine_too_good_to_be_true_i_can_use_it/
    • *Memantine creates an instant and ever present sense of urgency - there is something to be lost and much more to be gained at all times - time is the most valuable asset and it can’t be wasted at any cost (except when it comes to health, but that could also be considered time wasting, if you shorten your life you literally lose future time). Everything is basically a simple choice on Memantine, there’s no emotional push and pull when it comes to making decisions. *
    • At higher doses it’s also a great party drug (in safe conditions ofc). The amount of physical sensations it produces is immense, not all of them comfortable, but most are. The most uncomfortable being fingertip paresthesia, pins and needles type thing… if you told me this I would say ye that’s no prob but in reality I thought about quitting it because of this
    • Chronic use also produces a severe ‘on edge’ type feeling, esp above 25 mg. This is due to a global downregulation of GABA receptors caused by KCC2 downregulation. Exercise can offset this, but in my experience wasn’t enough and I’m an endurance athlete. Along with the fear of CV sides, this is the reason I decided not to use it chronically. That being said, I noticed STRONG ergogenic effects.
  • This futuristic kinda emotions and worldview were strongest on Memantine than any other drug I tried (tho’ I didn’t try any other disso except DXM). At one point I saw the future when I closed my eyes. With Armodafinil I would just spend every single moment of the day working for it. That said I should return to that spot soon

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