Berberine

5-16-2021 links: Nootropics reference:

Berberine #

• Antioxidant, anti-inflammatory, antitumour, antimicrobial, hepatoprotective, hypolipidemic, hypoglycemic.
  • Commonly used for SIBO and such.
• Glucose disposal agent: sort of insulin-memetic; they enhance glucose uptake into muscular glycogen instead of fat cells.
  • This effect is also seen with Ecklonia Cava, Bitter melon, and α-Lipoic Acid.
• Its metabolite, dihydroberberine: https://www.youtube.com/watch?v=zPAoGCy8BAA
  • Lower dosage and better absorption (100-200mg)
• https://raypeatforum.com/community/threads/berberine-insulin-resistance-help.32163/
  • Made somebody feel sleepy and had a negative effect on libido.
• Heaps of miscellaneous virtues: https://raypeatforum.com/community/threads/berberine.8316/
  • Lowers blood sugar by inhibiting aldose reductase, inducing Glycolysis. Increases insulin receptor expression.
  • Lowers LDL via upregulating LDLR mRNA, and downregulating transcription of PCSK9, increasing in the liver expression of LDLr.
• Protective effect on CNS disorders (azlheimers, schizophrenia, anxiety, etc.)
• 5mg/kg, i.p. Acutely increased noradrenaline (31%) serotonin (47%) dopamine (31%).
  • Chronic administration for 15 days increased NA (29%) serotonin (19%) and dopamine (52%).
• Can inhibit the release of noradrenaline via adrenergic α2 autoreceptors, and can antagonize D2 and agonize D1.
• Decreased serotonergic system activity via activation of somatodendritic 5-HT1A autoreceptors and inhibition of post-synaptic 5-HT1A and 5-HT2A/55-HT2C.
• Increases 17β-HSD mRNA.
• Inhibitory affect on glutamate receptors and can reduce glutamate, 5-HT and NE levels (contrary to the aforementioned evidence in the very same article… okay then)
• Affects the Sigma Receptor 1 similar to many antidepressants.
• Potentiates NGF.
• Can increase SERT
• Berberine alkaloids bind with the high-affinity benzodiazepene site on the GABA-A receptor.
• mTOR inhibitor.