DMT

links: Drugs reference: 4-30-2021

DMT (N,N-Dimethyltryptamine) #

• Agonizes 5-HT1A, 5-HT2A, 5-HT2C. Affinity for D1, α1-adrenergic, α2-adrenergic, imidazoline-1, and Sigma Receptor 1.

• The Bright Side of Psychedelics: Latest Advances and Challenges in Neuropharmacology
• VMAT2 inhibitor? Dimethyltryptamine and other hallucinogenic tryptamines exhibit substrate behavior at the serotonin uptake transporter and the vesicle monoamine transporter
• Psychedelics and immunomodulation: novel approaches and therapeutic opportunities
• Longevity and the Aging Brain: Psychedelic-Based Therapeutics for Neuroregeneration and Rejuvenation
  • DMT induces neurogenesis in the presence of selective 5-HT2A antagonism (ritanserin/ketanserin/volinanserin)!
• https://alieninsect.substack.com/p/your-brain-on-dmt
  • Alpha and gamma oscillations characterize feedback and feedforward processing in monkey visual cortex
    • Alpha waves are generated by deeper cortical layers and represent feedback activity (predictions) down the hierarchy, whereas Gamma mediates feed-forward/error signals going up the hierarchy.
  • Desynchronisation of alpha oscillations and a reduction of alpha power is one of the most consistently observed effects of the psychedelics in human neuroimaging studies, reflecting disruption of the high-level world model and its predictions.
  • Human brain effects of DMT assessed via EEG-fMRI (Timmermann, Carhart-Harris, et al)
    • Disrupts intra-network functional connectivity (network integrity).
    • Reduced alpha power+synchronization (thus less top-down signaling)
    • revealed a “drug-induced collapse of the defining principal gradient of the brain”. In other words, there was reduced segregation and definition between the levels of the sensory processing hierarchy, further indicating loss of control of the higher over lower order areas.
      • Indeed, that’s a common term. For instance: Flexing the principal gradient of the cerebral cortex to suit changing semantic task demands
        • Structure of the cerebral cortex is a primary goal of cognitive neuroscience. Recent work has revealed a principal gradient of intrinsic connectivity capturing the separation of sensory-motor cortex from transmodal regions of the DMN.
• JC says a tiny dose of Pramipexole makes it super smooth. He met twerking ice cream catgirl.
• Common: 20-40mg
• Strong: 40-60mg

IsoDMT #

So the N moved up a counterclockwise where it connects to the side chain.

• Like a soft version of the non-ISO thing without the associated intestinal problems, the body load and the difficulty focusing. The ISO-DMT seems to be a bit SEMAX-ey - it sort of feels ‘opening’, ‘positive’, ’easing’. A little silencing of the inner voice… About 3 days of interesingness… Pairs well with 4’-DMA-7,8-DHF from nootropics depot which adds a nice mood uplift to the background thing. Exercise feels more pleasant (after the fact) so I am guessing ISO-DMT is potentiating or multiplying the effects of any BDNF generated from DHF or exercise.
• Seems to come as fumarate, so inject it, basically. Maybe oral.
• Significantly reduced hallucinations but it retains the neurogenic/‘psychoplastogenic’ effects:
  • But it’s all about 5-HT2A. It both causes hallucinations and mediates the plasticity. Tabernanthalog is one such example
• Identification of Psychoplastogenic N,N‑Dimethylaminoisotryptamine (isoDMT) Analogues through Structure−Activity Relationship Studies
• Evaluation of Isotryptamine Derivatives at 5-HT2 Serotonin Receptors
• The Subjective Effects of Psychedelics May Not Be Necessary for Their Enduring Therapeutic Effects
  • 6-MeO-iso produces no head twitch response. 6-MeO-Iso is an even more potent psychoplastogen than 5-MeO.
• Synthesis and Evaluation of a Novel Series of N,N-Dimet hylisotryptamines (1984)
  • Old tryptamine studies… geez. No serotonin receptor subtypes.

Dosing #

• Hold a torch lighter 2-3 inches below the pipe (the bigger the ball the better) and rotate it. The smoke should be light and clear. If it’s thick, it’s overheated. Inhale lightly.
• Dab rig: heat until red hot, wait 20-30 seconds, then drop the DMT in dry, cover and pull. (Much more time cooling than with a regular dab)
• Best e-vape for a DMT breakthrough in one hit EVERY TIME - the E-mesh even stronger than an oil burner, I think. Pretty awesome too since it’s just 1 hit, and not 2-3. The Vandyvape RDA used isn’t around anymore so I might want a newer guide. Aegis Solo box mod and then Wish.com RDA, like this: https://www.wish.com/product/mesh-pro-rda-tank-24mm-adjustable-316ss-mesh-coil-atomizer-with-pin-bf-vaporizer-rebuilding-e-cigarette-608bc28f54f9e5e5f74753ea for a measly $5? Adeptus recommends it and says they’re just as good. And then buy a mouthpiece.

Chemistry #

It can appear grainy or even sticky like the result of some of these teks.

• https://wiki.dmt-nexus.me/Fumarates_to_Freebase_Conversion_TEK
  • It’s quite flawed because it oils out and gets tacky rather than beautiful crystalization. 5-MeO is less forgiving than DMT for this.
  • @ 150mg = / by 27.3
    • 150mg DMT into .9mL hot water until it dissolves completely.
    • 1.46g Na carbonate into 3.66 mL hot water
    • Slowly add the sodium carbonate mix to the DMT solution over the course of a minute.
    • Lid and shake for about 20 seconds.
    • Add 2.74mL of room temp H2O to the solution. Shake for 20 seconds.
    • Freeze for 5 mins, OR put in the fridge for 3-5 days.
    • The freebase will begin to surface by creating a golden layer atop cloudy carbonate water.
    • After the freebase fully surfaces and solidifies, you can simply pull it out and wash it with water in a separate container/through a coffee filter to take off any excess carbonate. (5-MeO is only water soluble at like 1mg/mL)
• Tehnically a more ghetto version of what’s done above: Half the dose in carbonate. Mix and crush them together in a glass container. Add enough water to cover it, then heat the container to evaporate the water. As soon as it looks “like wet but [not] watery anymore” stop warming up. Let the mix dry completely. Add it to water and it should be insoluble.
  • What you do after to remove any of the Na2CO3 is a bit unclear to me. You filter the water, which picks up excess and save the solid.
  • A non-polar oil will form which can be spread across the dish.
• Just dissolve in minimal water then add a water solution of sodium carbonate (soda ash) until it stops turning milky white upon addition. Then just put in frig for a couple days and collect the solid freebase. Or you can use any base at all beside sodium carbonate such as lye but then the freebase will fall out of solution more as sticky goo then you will just have to dry out and then scrap off as solid.
• https://wiki.dmt-nexus.me/Nontoxic_Freebase_Spice_Conversion similar to above.
  • Mix equal amounts on an evaporation dish and moisten dropwise. Spread evenly across the dish theinly and evenly.
• 100mg fumarate, 10mL of tap water. Add Na2CO3 solution presumably of similar volume. Let settle for a few ddays and the crystals can be collected: coffee filter, dissolved in acetone, and then evaporate the acetone.