Niacinamide

links: Niacin reference:

• Lots of virtues listed: https://www.functionalps.com/blog/2012/03/20/ray-peat-phd-on-therapeutic-effect-of-niacinamide/ 4-12-2021

Niacinamide #

Another no-flush form of supplemented niacin is Inositol hexanicotinate. It increases cell membrane permeability.

• Readily converts into the bioactive forms of niacin: NAD+, NADH, NADP, and NADPH.

• Lowers temperature and stress hormones.

• Can lower free fatty acids. Inhibits Lipolysis/Fatty Acid Oxidation at least in large doses.

• Nicotinamide reprograms adipose cellular metabolism and increases mitochondrial biogenesis to ameliorate obesity

• The Influence of Nicotinamide on Health and Disease in the Central Nervous System

  • Neuroprotective.
  • Upregulates liver X receptors.
  • NAD+ serves as a substrate for the synthesis of cADPR, used in calcium signalling, important for Neuroplasticity, especially in the hippocampus. However, a study showed that decreased niacin intake and cADPR levels enhanced spatial learning in adult male rats, and when nicotinamide (4g/kg (epic 45g HEQ)) was supplemented, it decreased. R

• Lowers Blood Glucose, probably via lowering stress hormones and gluconeogenesis. Debatable if it’s due to any burning of glycogen.

• It has a sedative, antiexcitatory effect (on cells.) Peat

• Prevents GI damage caused by NSAIDs (ie Aspirin) Gut

• Inhibits 11β-HSD type 1 and promotes type 2 (inhibits conversion) R

• Inhibits SIRT1? Need sources on this though.

• Downregulates DKK-1 expession in dermal papilla cells via diminishing H2O2-induced production of it. R R

Excess nicotinamide increases plasma Serotonin and Histamine levels #

• Depletes the body’s Methyl Group pool.
  • Excess nicotinamide inhibits methylation-mediated degradation of catecholamines in normotensives and hypertensives
• 100mg oral.
• Urinary N-methyl-2-pyridone-5-carboxamide and N-methylnicotinamide:
  • 
• After 5hr, plasma Trimethylglycine -~14% and Choline ~-10%:
  • 
• After 5hr, plasma Serotonin +60% and Histamine +25%:
  • 

Supplementation #

• Can go anywhere from 25-1000mg. The 1g+ dosages have benzodiazepine-like anxiolytic effects. Much higher, and it converts into NAD too quickly, and can have liver-damaging effects. It depletes Methyl Groups to some degree. Pairing it with betaine 1:1 can help with all that.
• High doses (1-1.5g) help with diabetes. Should be taken early, while niacin should be taken at dinner.