Fatty Acid Oxidation
links: reference: 6-3-2021
Fatty Acid Oxidation #
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Produces much more ROS than glucose oxidation.
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“During stress, free fatty acids are released from the tissues, and circulating in the bloodstream they are highly susceptible to oxidation… They contribute to the formation of the age pigment, Lipofuscin, which is an oxygen-wasting substance that’s found in the atheroma plaques in the damaged blood vessels. Iron and calcium accumulation adds to the tissue damage.” Peat
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The lactate produced under the influence of excessive fat metabolism stimulates the release of Endorphins, which are lipolytic, releasing more free fatty acids from the tissues.
Primarly facillitated in the MTP (enzyme complex in the Inner Mitochondrial Membrane) beta-oxidation ultimately generates Acetyl-CoA, NADH, and FADH2.
- [The effect of substrate utilization, manipulated by nicotinic acid, on excess postexercise oxygen consumption]
- FFA levels during the nicotinic acid trial were significantly lower than control values during both exercise and recovery. Serum glycerol levels were also significantly lower during exercise in the nicotinic acid trial, indicative of a reduction in lipolysis.
- RER was not significantly different at rest or during exercise; however, RER values were significantly lower during recovery in the control trial, indicative of greater fat oxidation.