NAD+
2021-12-03 links: reference:
NAD+ #
Oxidized form of NAD, which is stored in the liver. Created from Niacinamide via NAMPT.
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SARM1 is a metabolic sensor activated by an increased NMN-NAD+ ratio to trigger axon degeneration
- SARM1 is a NAD+ cleaving enzyme whose activation triggers Wallerian degeneration (axon destruction/deMyelination). Loss of NMNAT2, which converts Nicotinamide Mononucleotide to NAD+, activates SARM1 via an unknown mechanism,
- But it’s known it isn’t preventing SARM1 NAD+ depletion R. Mice lacking NMAT2 die before birth but are completely rescued by SARM1 deletion.
- SARM1 is a NAD+ cleaving enzyme whose activation triggers Wallerian degeneration (axon destruction/deMyelination). Loss of NMNAT2, which converts Nicotinamide Mononucleotide to NAD+, activates SARM1 via an unknown mechanism,
Supplementation #
Can be taken intranasally for uptake into the Hypothalamus and Hippocampus.