Trimethylglycine

links: reference: 8-18-2021

Trimethylglycine (TMG) #

(Betaines are a class of compounds; ‘betaine’ = TMG) - neutral with a cationic funuctional group. An amino acid derivative and a betaine. Thorne’s Niacel contains it (along with Nicotinamide Riboside.) Supports Methylation by converting Homocysteine into Methionine.

• Adverse Signaling of Scavenger Receptor Class B1 and PGC1s in Alcoholic Hepatosteatosis and Steatohepatitis and Protection by Betaine in Rat
  • Downregulates PGC-1β and lipogenic genes, and upregulates PGC-1α.
• https://men-elite.com/2018/11/06/betaine/
  • Can aid in nitrogen retention in muscle growth due to its methionine sparing effects?
  • Improves cellular hydration by being osmolytic.
  • When donated its methyl donors, it is metabolized to glycine.
  • Increases Growth Hormone and IGF-1 and synthesis of phospholipids.
  • Lowers Cortisol.
  • Effect of 15 days of betaine ingestion on concentric and eccentric force outputs during isokinetic exercise
    • Take 2.5g minimum for increasing levels preworkout; SOh, and the Nightbuds measure sleep as well, but not comparable to that of the Apple Watch SE I’d imaginepikes 40-60 minutes after ingestion. Accumulates in the body in a similar fashion to creatine.

High Dose #

• https://www.ergo-log.com/choline-betaine-more-muscles-less-fat.html
  • Higher Dietary Choline and Betaine Intakes Are Associated with Better Body Composition in the Adult Population of Newfoundland, Canada
• https://www.ergo-log.com/betaine-gives-bodybuilders-more-muscle-and-less-fat.html
• https://www.ergo-log.com/betaine-fat-loss.html
  • Mice. 10-15g HED!!
  • Betaine Supplementation Enhances Lipid Metabolism and Improves Insulin Resistance in Mice Fed a High-Fat Diet
    • For future reference for Body fat, here are some genes it changed regulation of: such as higher PPAR-α and lower PPAR-γ.
• https://ergo-log.com/betaine-increases-testosterone-lowers-cortisol-after-strength-training.html
  • 1.25 twice a day.
  • Effects of short-term betaine supplementation on muscle endurance and indices of endocrine function following acute high-intensity resistance exercise in young athletes
    • HOLY SHIT 500->1500ng/dl??? and then 1000ng/dl before workout.