Folate

links: Vitamins & Minerals reference: 7-3-2021

Folate (B9) #

A deficiency can cause paranoia and apparently mania.

• Travis says Autism is a form of cerebral folate deficiency: bovine milk autoimmunity; antifolate receptor antibodies, which predictably and reliably lead to an elevation in cerebral Homocysteine—and a decrease in dNA synthesis, Myelination, Tetrahydrobiopterin, and acetylcholine in same
  • Can you think of anything else that can so well explain the established link between milk, autism, vaccines, folate, and birth defects? R
    • A milk-free diet downregulates folate receptor autoimmunity in cerebral folate deficiency syndrome
  • Tetrahydrobiopterin as a treatment for autism spectrum disorders: a double-blind, placebo-controlled trial improved secondary measures like social awareness, mannerisms, etc.

Methylation #

• THF is a methyl donor via SHMT, whereby it becomes 5,10-methylene THF.
• 
  • NADPH is cofactor for the 2xDFHR at the begining.
  • PFCT = proton-coupled folate transporter: regulates intestinal absorption and its delivery into the CNS.

Folic Acid #

• Simply the synthetic form of Folate; converts into it in the body.
• Methylated version is the best< I believe, like supplementing L-5-MTHF directly.
• But Masterjohn makes the case for unmethylated being better if you’re B12 deficient. https://www.youtube.com/watch?v=cHrwIXJkz1k. Folic acid is also actually more stable and easily digestible. Supplementation may reduce Zinc absorption.