BAX
2023-05-17:
Apoptosis regulator BAX (Bcl-2-like protein 4) #
- Increases the opening of mitochondrial voltage-dependent anion channels -> loss of ΔΨ -> release of cytochrome C. There’s also something called MAC, where BAX or Bak form an oligomeric pore in the Mitochondrial Outer Membrane
- Stimulated by heat, H2O2, low/high pH, etc. And activated by binding proteins like Bcl-2, p53.