B1

links: Vitamins & Minerals reference: 4-12-2021

B1 (Thiamine) #

• https://raypeatforum.com/community/threads/borderline-hypothyroid-histamine-intolerance-leaky-gut-hydrogen-sulfide-sibo-need-help.39296/post-618445

• https://www.youtube.com/watch?v=-DxvSUEVT_4 #

• Synergizes well with Magnesium: it is required to convert B1 to its active form. As thiamine is a cofactor for magnesium, high doses of magnesium can lower thiamine, and vice versa.
• Increases production of NADPH.
• Can cause issues with sun.
• Helps with Glucose Oxidation; can lower Blood Glucose
• In rats with deficiency, a decrease of Glutamate uptake in the prefrontal cortex was observed and was accompanied by a deficit in Morris water maze learning. Indeed, (sudden?) increases increase glu activity.
• B6 inhibits its synthesis.
• RPF: Anti-Thiamine factors some bacteria. Certain polyphenols like Caffeic acid, Chlorogenic Acid, Tannin, and flavonoids like Quercetin, Rutin interfere with absorption/digestion.
  • Thiamine deficiency in Thailand

Cofactor #

• Pyruvate Dehydrogenase

Absorption #

• The body stores ~25-30mg at a time, 80% of which is TDP. And 40-50% of it is found in skeletal muscle. Half life of about 8-20 days. It is excreted as free thiamin.
• Its active form is thiamine pyrophosphate aka diphosphate (95% of the time in animal products) or triphosphate.
  • Free thiamin when is absorbed after intestinal phosphatases. For some reason though the intestinal cells also express thiamin pyrophosphokinase to revert it.
• Can be destroyed at the methylene bridge in >8 pH or heat, like cooking in water.

Supplementation #

• There’s thiamine HCL and thiamine mononitrate; the latter is non-hygroscopic. Allithiamine, sulbutiamine, and TTFD (tastes awful) are also options.

  • HCL has 3~5% bioavailability.

• ~1mg RDI.

• Megadosing doesn’t seem to cause problems outside of magnesium depletion/usage, though apparently it might make you smell strange.