Platelet
2022-10-17:
Platelet (Thromcobyte) #
They initiate blood clots and stuff.
- They release serotonin (at eachother?), and have 5-HT2A to mediates platelet aggregation. Serotonin stimulates the production of nitric oxide especially in undamaged cells, which controls platelet aggregation. They also uptake GABA, aspartate, glutama,te and glycine.
- They do not produce serotonin, but rather receive it via SERT across the plasma membrane, or via VMAT-2 across the δ-granule membrane.
- Thus, SSRIs decrease platelet 5-HT content (sometimes <10% in patients) and can put one at risk for abnormal bleeding but decreased risk for arterial occlusive events.
- SSRIs decrease IFN-γ secretion.
- Thus, SSRIs decrease platelet 5-HT content (sometimes <10% in patients) and can put one at risk for abnormal bleeding but decreased risk for arterial occlusive events.
- They do not produce serotonin, but rather receive it via SERT across the plasma membrane, or via VMAT-2 across the δ-granule membrane.
- Platelets contain mRNA and ribosomes. Proteins are stored in granules, shose contents are released at sites of vascular damage.
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