Lactate Dehydrogenase

links: Enzyme reference: https://men-elite.com/2019/11/08/best-ways-to-reduce-exercise-induced-serotonin-and-optimize-carbon-dioxide-production/ 4-21-2021

Lactate Dehydrogenase (LDH) #

Reversibly catalyzes the conversion of Lactate to Pyruvate, as it converts NAD+ to NADH and back.

• Can be inhibited by B1, Methylene Blue. On 4-12 I got 143 IU/L. Reference range 121-224. High levels more or less mean one is leaning to the side of anaerobic glycolysis.

Isoenzymes #

• 
  • Interesting how there’s something of an inverse correlation (or whatever you call it) here. I think I recall haidut saying something like this before. Heart needs to be running 24/7 and can’t rely on glucose, yet liver needs to stay away from it
• LDHA (subunit M) (gene LDHA) a monomer.
• LDHB (Subunit H)
• LDHC
• So LDH is a tetramer, and it can have a different permutation of the 2 monomers:
  • LDH-1 = HHHH
    • Found in brain, heart, RBCs
  • LDH-2 = HHHM
    • Predominant form in the serum.
  • LDH-3 = HHMM
  • LDH-4 = HMMM
    • Pancreas, kidneys, placenta
  • LDH-5 = MMMM
    • Liver, striated muscle, brain