Neurotrophic Factors

2022-03-11: reference:

Neurotrophic Factors #

• NOT neurotrophins.
• Usually peptides/small proteins, and usually through RTK: promote growth/survival/differentation of Neurons.
• They block apoptosis-triggering processes.
• Seems to be quite esoteric whow they’re even synthesized and transported.

• Neurotrophins:
  • BDNF
  • NGF
  • Neurotrophin-3/4
• GDNF (Glial cell-line derived):
  • Artemin
  • Neurturin
  • Persephin
• CNTF (ciliary neurotrophic factor):
  • LIF
  • IL-6
  • Prolactin
  • Growth Hormone
  • Leptin
  • Interferon
  • Oncostatin M
• EGF/TGF
  • TGF-β/α, EGF
  • There are also numerous proteins wit ‘EGF-like domains’
• Ephrins
• VGF (not even an acronym).
• Other random stuff like IGF-1, VEGF, FGF15, PDGF, IL-1,2,3,5,8, neurotractin, glia maturation factor
• CDNF
• MANF