AF710B

2025-05-01:

AF710B (ANAVEX 3-71) #

• M1 AChR agonist-PAM (it both is an agonist and potentiates the binding of other agonists, lol? If not maybe it’s just a PAM) and σ1 agonist.
  • Denzel thinks it’s the best sigma 1 agonist to top it off. It’s truly himothy
• AF710B, a Novel M1/σ1 Agonist with Therapeutic Efficacy in Animal Models of Alzheimer’s Disease
• AF710B, an M1/sigma-1 receptor agonist with long-lasting disease-modifying properties in a transgenic rat model of Alzheimer’s disease
• Pharmacokinetic stuff: Population-Based Characterization of the Pharmacokinetics and Food Effect of ANAVEX3-71, a Novel Sigma-1 Receptor and Allosteric M1 Muscarinic Receptor Agonist in Development for Treatment of Frontotemporal Dementia, Schizophrenia, and Alzheimer Disease

Dose #

• 4 hour half life. Its main M8 metabolite has a 7 hour half life with 25-50% less binding at the relevant sites.